IP6K1 [The Human Chemical-Genetic Interaction Map Project]

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======= IP6K1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IP6K1
  * **<color #00a2e8>Official Name</color>**: inositol hexakisphosphate kinase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9807|9807]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92551|Q92551]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IP6K1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IP6K1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606991|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IPK|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|inositol hexakisphosphate 3-kinase activity|
|inositol hexakisphosphate 1-kinase activity|
|inositol hexakisphosphate 5-kinase activity|
|inositol hexakisphosphate kinase activity|
|inositol phosphate biosynthetic process|
|negative regulation of cold-induced thermogenesis|
|phosphatidylinositol phosphorylation|
|inositol phosphate metabolic process|
|polyol biosynthetic process|
|lipid phosphorylation|
|polyol metabolic process|
|alcohol biosynthetic process|
|fibrillar center|
|regulation of cold-induced thermogenesis|
|phosphatidylinositol metabolic process|
|organic hydroxy compound biosynthetic process|
|lipid modification|
|glycerophospholipid metabolic process|
|alcohol metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|organic hydroxy compound metabolic process|
|organophosphate biosynthetic process|
|small molecule biosynthetic process|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|phosphorylation|
|ATP binding|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp116|AICAR 240μM R03 exp116]]|-2.16|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-2.06|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-2.04|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-1.91|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.85|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.84|
|[[:results:exp16|DABN 2μM R00 exp16]]|-1.84|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|5.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.698|
|[[:human genes:k:kidins220|KIDINS220]]|0.622|
|[[:human genes:x:xpr1|XPR1]]|0.58|
|[[:human genes:i:ip6k2|IP6K2]]|0.569|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17594
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IP6K1 Expression in NALM6 Cells: 5.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>