IP6K1

Entrez Summary: N/A
UniProt Summary: Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
AICAR 240μM R03 exp116	-2.16
SNS-032 15μM R08 exp443	-2.06
Thimerosal 0.85μM R08 exp529	-2.04
BI-2536 0.02μM R03 exp96	-1.91
Pimelic-diphenylamide-106 5μM R00 exp28	-1.85
5-Fluorouracil 20μM R00 exp2	-1.84
DABN 2μM R00 exp16	-1.84
Arsenate 40μM R06 exp264	5.78

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

inositol hexakisphosphate 3-kinase activity
inositol hexakisphosphate 1-kinase activity
inositol hexakisphosphate 5-kinase activity
inositol hexakisphosphate kinase activity
inositol phosphate biosynthetic process
negative regulation of cold-induced thermogenesis
phosphatidylinositol phosphorylation
inositol phosphate metabolic process
polyol biosynthetic process
lipid phosphorylation
polyol metabolic process
alcohol biosynthetic process
fibrillar center
regulation of cold-induced thermogenesis
phosphatidylinositol metabolic process
organic hydroxy compound biosynthetic process
lipid modification
glycerophospholipid metabolic process
alcohol metabolic process
phospholipid metabolic process
glycerolipid metabolic process
organic hydroxy compound metabolic process
organophosphate biosynthetic process
small molecule biosynthetic process
organophosphate metabolic process
cellular lipid metabolic process
negative regulation of multicellular organismal process
lipid metabolic process
phosphorylation
ATP binding
small molecule metabolic process