IP6K2
Gene Information
- Official Symbol: IP6K2
- Official Name: inositol hexakisphosphate kinase 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 51447
- UniProt: Q9UHH9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| IPK |
GO Terms
| cellular response to flavonoid |
| flavonoid binding |
| response to flavonoid |
| inositol hexakisphosphate 5-kinase activity |
| inositol hexakisphosphate kinase activity |
| phosphate ion transport |
| inositol phosphate biosynthetic process |
| phosphatidylinositol phosphorylation |
| inositol phosphate metabolic process |
| polyol biosynthetic process |
| lipid phosphorylation |
| type I interferon signaling pathway |
| cellular response to type I interferon |
| response to type I interferon |
| polyol metabolic process |
| alcohol biosynthetic process |
| fibrillar center |
| inorganic anion transport |
| phosphatidylinositol metabolic process |
| negative regulation of cell growth |
| organic hydroxy compound biosynthetic process |
| lipid modification |
| negative regulation of growth |
| glycerophospholipid metabolic process |
| alcohol metabolic process |
| phospholipid metabolic process |
| glycerolipid metabolic process |
| regulation of cell growth |
| organic hydroxy compound metabolic process |
| organophosphate biosynthetic process |
| cell junction |
| anion transport |
| small molecule biosynthetic process |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| regulation of growth |
| cytokine-mediated signaling pathway |
| positive regulation of cell death |
| innate immune response |
| organophosphate metabolic process |
| defense response to other organism |
| cellular lipid metabolic process |
| cellular response to cytokine stimulus |
| cellular response to oxygen-containing compound |
| response to cytokine |
| lipid metabolic process |
| phosphorylation |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| ion transport |
| ATP binding |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of cell death |
| small molecule metabolic process |
| immune response |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| AICAR 240μM R05 exp211 | -1.79 |
| Citral 50μM R06 exp274 | -1.7 |
| BI-6727 0.0125μM R03 exp97 | 1.72 |
| GSK461364A 0.005μM R03 exp125 | 1.73 |
| BI-2536 0.0042μM R03 exp95 | 2.21 |
| Arsenate 40μM R06 exp264 | 6.42 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16737
- Expression level (log2 read counts): 6.18
Expression Distribution
IP6K2 Expression in NALM6 Cells: 6.18