IPPK [The Human Chemical-Genetic Interaction Map Project]

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======= IPPK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IPPK
  * **<color #00a2e8>Official Name</color>**: inositol-pentakisphosphate 2-kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64768|64768]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H8X2|Q9H8X2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IPPK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IPPK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619043|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a kinase that phosphorylates position 2 of inositol-1,3,4,5,6-pentakisphosphate to form inositol-1,2,3,4,5,6-hexakisphosphate (InsP6). InsP6 has a variety of functions, including stimulation of DNA repair, endocytosis, and mRNA export. [provided by RefSeq, Nov 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis. {ECO:0000269|PubMed:12084730, ECO:0000269|PubMed:15967797}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ins P5 2-kin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|inositol pentakisphosphate 2-kinase activity|
|inositol phosphorylation|
|positive regulation of transcription of nucleolar large rRNA by RNA polymerase I|
|inositol metabolic process|
|regulation of transcription of nucleolar large rRNA by RNA polymerase I|
|positive regulation of transcription by RNA polymerase I|
|carbohydrate phosphorylation|
|inositol phosphate biosynthetic process|
|regulation of transcription by RNA polymerase I|
|molecular adaptor activity|
|inositol phosphate metabolic process|
|polyol biosynthetic process|
|polyol metabolic process|
|alcohol biosynthetic process|
|cellular carbohydrate metabolic process|
|organic hydroxy compound biosynthetic process|
|alcohol metabolic process|
|organic hydroxy compound metabolic process|
|carbohydrate metabolic process|
|organophosphate biosynthetic process|
|small molecule biosynthetic process|
|nucleolus|
|organophosphate metabolic process|
|phosphorylation|
|ATP binding|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|small molecule metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-2.69|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-2.43|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.25|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2.23|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2.22|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.21|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-2.18|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.18|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.15|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.11|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-2.05|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-1.99|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.97|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.97|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.96|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-1.91|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-1.88|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.83|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-1.77|
|[[:results:exp539|42°C R08 exp539]]|-1.73|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-1.73|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.73|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-1.73|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|1.84|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.9|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.97|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.99|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|2.09|
|[[:results:exp148|SB202190 10μM R03 exp148]]|2.13|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|2.15|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.16|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.32|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|2.49|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.67|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|2.72|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|2.88|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|3.1|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|3.18|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|3.38|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|4.03|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|4.72|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|8.43|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:ipmk|IPMK]]|0.692|
|[[:human genes:i:itpk1|ITPK1]]|0.514|
|[[:human genes:p:pds5b|PDS5B]]|0.449|
|[[:human genes:r:rrm1|RRM1]]|0.437|
|[[:human genes:n:nip7|NIP7]]|0.417|
|[[:human genes:n:nelfb|NELFB]]|0.409|
|[[:human genes:n:nelfa|NELFA]]|0.408|
|[[:human genes:a:anp32a|ANP32A]]|0.408|
|[[:human genes:n:nprl2|NPRL2]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 40/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|9/28|
|bone|0/26|
|breast|3/33|
|central nervous system|1/56|
|cervix|1/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|3/16|
|ovary|2/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2168
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IPPK Expression in NALM6 Cells: 4.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>