IPPK

Entrez Summary: The protein encoded by this gene is a kinase that phosphorylates position 2 of inositol-1,3,4,5,6-pentakisphosphate to form inositol-1,2,3,4,5,6-hexakisphosphate (InsP6). InsP6 has a variety of functions, including stimulation of DNA repair, endocytosis, and mRNA export. [provided by RefSeq, Nov 2010].
UniProt Summary: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis. {ECO:0000269|PubMed:12084730, ECO:0000269|PubMed:15967797}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CAY10603 0.55μM R08 exp467	-2.69
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-2.43
Tubacin 1.6μM R07 exp416	-2.25
Hydroxyurea 100μM R07 exp329	-2.23
Quercetin 20μM R08 exp517	-2.22
Taxol 0.004μM R03 exp103	-2.21
Demecolcine 0.03μM R05 exp228	-2.18
Thapsigargin 0.005μM R07 exp407	-2.18
Mdivi-1 15μM R05 exp217	-2.15
Cryptotanshinone 12μM R05 exp227	-2.11
SNS-032 15μM R08 exp443	-2.05
Cabazitaxel 0.001μM R05 exp223	-1.99
BML-284 0.09μM R08 exp460	-1.97
Colchicine 0.009μM R05 exp215	-1.97
UM0125461 0.74μM R02 exp84	-1.96
Bafilomycin-A1 0.009μM R08 exp454	-1.91
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-1.88
UMK57 1μM R01 exp59	-1.83
BI-2536 0.02μM R03 exp96	-1.77
42°C R08 exp539	-1.73
GSK461364A 0.1μM R03 exp126	-1.73
JQ1 0.8μM R08 exp435	-1.73
UMK57 0.6μM R03 exp107	-1.73
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	1.84
Nocodazole 0.1μM R03 exp94	1.9
HMS-I2 10μM R06 exp288	1.97
MK-1775 0.32μM R02 exp75	1.99
Phenformin 20μM R05 exp212	2.09
SB202190 10μM R03 exp148	2.13
HMS-I2 5μM R06 exp287	2.15
BI-2536 0.0042μM R03 exp95	2.16
Oligomycin-A 2μM R00 exp25	2.32
Rapamycin 1μM R00 exp29	2.49
Chloramphenicol 20μM R00 exp13	2.67
PF-06409577 20μM R07 exp389	2.72
Hypoxia 5%O2 R04 exp191	2.88
MLN-4924 0.2μM R00 exp21	3.1
Mubritinib 0.2μM R02 exp65	3.18
QNZ 0.01μM R08 exp439	3.38
Trimetrexate 0.03μM R08 exp535	4.03
Mubritinib 0.2μM R01 exp48	4.72
Arsenate 40μM R06 exp264	8.43

Global Fraction of Cell Lines Where Essential: 40/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	9/28
bone	0/26
breast	3/33
central nervous system	1/56
cervix	1/4
colorectal	0/17
esophagus	1/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	2/75
lymphocyte	3/16
ovary	2/26
pancreas	1/24
peripheral nervous system	1/16
plasma cell	2/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

inositol pentakisphosphate 2-kinase activity
inositol phosphorylation
positive regulation of transcription of nucleolar large rRNA by RNA polymerase I
inositol metabolic process
regulation of transcription of nucleolar large rRNA by RNA polymerase I
positive regulation of transcription by RNA polymerase I
carbohydrate phosphorylation
inositol phosphate biosynthetic process
regulation of transcription by RNA polymerase I
molecular adaptor activity
inositol phosphate metabolic process
polyol biosynthetic process
polyol metabolic process
alcohol biosynthetic process
cellular carbohydrate metabolic process
organic hydroxy compound biosynthetic process
alcohol metabolic process
organic hydroxy compound metabolic process
carbohydrate metabolic process
organophosphate biosynthetic process
small molecule biosynthetic process
nucleolus
organophosphate metabolic process
phosphorylation
ATP binding
positive regulation of transcription, DNA-templated
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
small molecule metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process