IRAK3

Gene Information

Official Symbol: IRAK3
Official Name: interleukin 1 receptor associated kinase 3
Aliases and Previous Symbols: N/A
Entrez ID: 11213
UniProt: Q9Y616
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010].
UniProt Summary: Inhibits dissociation of IRAK1 and IRAK4 from the Toll- like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex. {ECO:0000250|UniProtKB:Q8K4B2, ECO:0000269|PubMed:10383454}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17176
Expression level (log2 read counts): 0.94

Expression Distribution

Pkinase Tyr
Death
Pkinase

regulation of macrophage tolerance induction
positive regulation of macrophage tolerance induction
negative regulation of macrophage cytokine production
positive regulation of tolerance induction
response to peptidoglycan
regulation of macrophage cytokine production
negative regulation of interleukin-12 production
regulation of tolerance induction
negative regulation of cytokine production involved in immune response
MyD88-dependent toll-like receptor signaling pathway
negative regulation of production of molecular mediator of immune response
negative regulation of toll-like receptor signaling pathway
negative regulation of interleukin-6 production
response to exogenous dsRNA
response to dsRNA
regulation of interleukin-12 production
negative regulation of innate immune response
negative regulation of tumor necrosis factor production
negative regulation of cytokine-mediated signaling pathway
negative regulation of tumor necrosis factor superfamily cytokine production
negative regulation of response to cytokine stimulus
regulation of toll-like receptor signaling pathway
negative regulation of protein complex disassembly
negative regulation of MAP kinase activity
negative regulation of NF-kappaB transcription factor activity
regulation of cytokine production involved in immune response
negative regulation of response to biotic stimulus
interleukin-1-mediated signaling pathway
toll-like receptor signaling pathway
regulation of protein complex disassembly
negative regulation of immune effector process
pattern recognition receptor signaling pathway
negative regulation of protein serine/threonine kinase activity
negative regulation of protein catabolic process
regulation of interleukin-6 production
regulation of production of molecular mediator of immune response
regulation of tumor necrosis factor production
negative regulation of immune response
regulation of tumor necrosis factor superfamily cytokine production
positive regulation of NF-kappaB transcription factor activity