IRF2 [The Human Chemical-Genetic Interaction Map Project]

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======= IRF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IRF2
  * **<color #00a2e8>Official Name</color>**: interferon regulatory factor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3660|3660]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P14316|P14316]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IRF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IRF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147576|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation. {ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:15226432, ECO:0000269|PubMed:18514056, ECO:0000269|PubMed:9540062}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IRF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to type I interferon|
|type I interferon signaling pathway|
|response to type I interferon|
|interferon-gamma-mediated signaling pathway|
|cellular response to interferon-gamma|
|response to interferon-gamma|
|defense response to virus|
|response to virus|
|blood coagulation|
|coagulation|
|hemostasis|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|focal adhesion|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|wound healing|
|regulation of body fluid levels|
|cell population proliferation|
|response to wounding|
|cytokine-mediated signaling pathway|
|DNA-binding transcription factor activity|
|innate immune response|
|negative regulation of transcription by RNA polymerase II|
|defense response to other organism|
|cellular response to cytokine stimulus|
|immune effector process|
|response to cytokine|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-3.41|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.27|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-2.22|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-2.17|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-2|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-1.95|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-1.95|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-1.82|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-1.76|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-1.72|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.74|
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.74|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.93|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|1.95|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|1.95|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.07|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.08|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|2.11|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|2.12|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.15|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.17|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.25|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.28|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.41|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|3.02|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|3.09|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|3.13|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|3.17|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|3.48|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|3.96|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|4.28|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|4.51|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|4.55|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:l:lamtor2|LAMTOR2]]|0.442|
|[[:human genes:w:wdr24|WDR24]]|0.423|
|[[:human genes:f:flcn|FLCN]]|0.416|
|[[:human genes:e:eif4g1|EIF4G1]]|0.412|
|[[:human genes:w:wdr59|WDR59]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15416
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IRF2 Expression in NALM6 Cells: 4.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>