IRF2

Entrez Summary: N/A
UniProt Summary: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation. {ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:15226432, ECO:0000269|PubMed:18514056, ECO:0000269|PubMed:9540062}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bortezomib 0.005μM R00 exp6	-3.41
Cerivastatin 0.15μM R05 exp226	-2.27
BVD-523 15μM R02 exp67	-2.22
MSC2530818 10μM R07 exp379	-2.17
Fluvastatin 2.2μM R06 exp282	-2
Azithromycin 100μM R08 exp452	-1.95
NN-Dimethylsphingosine 2.5μM R08 exp508	-1.95
UMK57 0.6μM R03 exp107	-1.82
Nicotine 3000μM R08 exp510	-1.76
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-1.72
2-Deoxy-D-glucose 800μM R05 exp214	1.74
LB-100 2μM R05 exp210	1.74
Aphidicolin 0.4μM R08 exp440	1.93
Radicicol 0.16μM R05 exp242	1.95
Vincristine 0.0005μM R04 exp190	1.95
MS023 7μM R03 exp135	2.07
3-Bromopyruvate 7μM R04 exp175	2.08
All-trans-Retinoic-Acid 40μM R07 exp334	2.11
Dinaciclib 0.007μM R07 exp355	2.12
THZ531 0.225μM R08 exp444	2.15
Benzoate 20000μM R08 exp456	2.17
LY2090314 0.003μM R08 exp499	2.25
Nutlin-3A 1.6μM R06 exp294	2.28
5-Fluorouracil 20μM R00 exp2	2.41
Actinomycin-D 0.001μM R00 exp3	3.02
6-Thio-2-deoxyguanosine 2μM R06 exp259	3.09
Betulinic acid 10 to 15μM on day4 R05 exp222	3.13
MLN-4924 0.2μM R00 exp21	3.17
TRAIL 50ng/ml R00 exp36	3.48
TRAIL 5ng/ml R00 exp35	3.96
Olaparib 4μM R08 exp512	4.28
Talazoparib 0.006μM R06 exp299	4.51
Diepoxybutane 3μM R07 exp354	4.55

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	1/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cellular response to type I interferon
type I interferon signaling pathway
response to type I interferon
interferon-gamma-mediated signaling pathway
cellular response to interferon-gamma
response to interferon-gamma
defense response to virus
response to virus
blood coagulation
coagulation
hemostasis
RNA polymerase II regulatory region sequence-specific DNA binding
focal adhesion
DNA-binding transcription activator activity, RNA polymerase II-specific
wound healing
regulation of body fluid levels
cell population proliferation
response to wounding
cytokine-mediated signaling pathway
DNA-binding transcription factor activity
innate immune response
negative regulation of transcription by RNA polymerase II
defense response to other organism
cellular response to cytokine stimulus
immune effector process
response to cytokine
negative regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
response to other organism
response to external biotic stimulus
response to biotic stimulus
negative regulation of RNA metabolic process
defense response
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process