IRF5

Entrez Summary: This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative promoter use and alternative splicing result in multiple transcript variants, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Dec 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

IRF-3
IRF

response to peptidoglycan
response to muramyl dipeptide
positive regulation of interferon-alpha production
regulation of interferon-alpha production
positive regulation of interferon-beta production
positive regulation of interleukin-12 production
regulation of interferon-beta production
regulation of interleukin-12 production
type I interferon signaling pathway
cellular response to type I interferon
response to type I interferon
interferon-gamma-mediated signaling pathway
positive regulation of type I interferon production
regulation of type I interferon production
cellular response to interferon-gamma
response to interferon-gamma
defense response to virus
transcription regulatory region DNA binding
response to virus
response to molecule of bacterial origin
sequence-specific DNA binding
DNA-binding transcription activator activity, RNA polymerase II-specific
positive regulation of cytokine production
response to peptide
positive regulation of apoptotic process
positive regulation of programmed cell death
cytokine-mediated signaling pathway
response to bacterium
regulation of cytokine production
positive regulation of cell death
innate immune response
defense response to other organism
response to organonitrogen compound
cellular response to cytokine stimulus
response to drug
identical protein binding
response to nitrogen compound
immune effector process
response to cytokine
positive regulation of transcription by RNA polymerase II