IRF9

Entrez Summary: N/A
UniProt Summary: Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
I-BRD9 4μM R07 exp365	-2.04
Hypoxia 5%O2 R04 exp191	1.84

IRF
IRF-3

type I interferon signaling pathway
cellular response to type I interferon
response to type I interferon
interferon-gamma-mediated signaling pathway
cellular response to interferon-gamma
response to interferon-gamma
defense response to virus
response to virus
transcription by RNA polymerase II
RNA polymerase II proximal promoter sequence-specific DNA binding
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
cytokine-mediated signaling pathway
DNA-binding transcription factor activity
innate immune response
defense response to other organism
cellular response to cytokine stimulus
immune effector process
nucleobase-containing compound biosynthetic process
response to cytokine
heterocycle biosynthetic process
aromatic compound biosynthetic process
response to other organism
organic cyclic compound biosynthetic process
response to external biotic stimulus
response to biotic stimulus
defense response
DNA-binding transcription factor activity, RNA polymerase II-specific
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
immune response
gene expression