IRS1 [The Human Chemical-Genetic Interaction Map Project]

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======= IRS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IRS1
  * **<color #00a2e8>Official Name</color>**: insulin receptor substrate 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3667|3667]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35568|P35568]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IRS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IRS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147545|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). {ECO:0000250, ECO:0000269|PubMed:16878150}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PH|
|IRS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|insulin receptor complex|
|positive regulation of fatty acid beta-oxidation|
|insulin-like growth factor receptor signaling pathway|
|transmembrane receptor protein tyrosine kinase adaptor activity|
|positive regulation of fatty acid oxidation|
|insulin-like growth factor receptor binding|
|positive regulation of glycogen biosynthetic process|
|positive regulation of glycogen metabolic process|
|regulation of fatty acid beta-oxidation|
|interleukin-7-mediated signaling pathway|
|phosphatidylinositol 3-kinase binding|
|positive regulation of insulin receptor signaling pathway|
|insulin receptor binding|
|positive regulation of cellular response to insulin stimulus|
|positive regulation of lipid catabolic process|
|cellular response to interleukin-7|
|regulation of glycogen biosynthetic process|
|regulation of glucan biosynthetic process|
|response to interleukin-7|
|regulation of fatty acid oxidation|
|positive regulation of phosphatidylinositol 3-kinase activity|
|phosphatidylinositol 3-kinase signaling|
|negative regulation of insulin receptor signaling pathway|
|positive regulation of fatty acid metabolic process|
|regulation of glycogen metabolic process|
|SH2 domain binding|
|negative regulation of cellular response to insulin stimulus|
|positive regulation of lipid kinase activity|
|regulation of polysaccharide biosynthetic process|
|positive regulation of glucose import|
|positive regulation of glucose metabolic process|
|negative regulation of insulin secretion|
|phosphotyrosine residue binding|
|regulation of polysaccharide metabolic process|
|positive regulation of glucose transmembrane transport|
|negative regulation of peptide hormone secretion|
|positive regulation of phospholipid metabolic process|
|regulation of phosphatidylinositol 3-kinase activity|
|SH3/SH2 adaptor activity|
|protein kinase C binding|
|regulation of lipid catabolic process|
|regulation of glucose import|
|cellular response to fatty acid|
|positive regulation of cellular carbohydrate metabolic process|
|regulation of lipid kinase activity|
|negative regulation of hormone secretion|
|regulation of insulin receptor signaling pathway|
|phosphatidylinositol-mediated signaling|
|regulation of cellular response to insulin stimulus|
|regulation of glucose transmembrane transport|
|inositol lipid-mediated signaling|
|caveola|
|positive regulation of carbohydrate metabolic process|
|response to fatty acid|
|regulation of phospholipid metabolic process|
|regulation of fatty acid metabolic process|
|insulin receptor signaling pathway|
|regulation of carbohydrate biosynthetic process|
|regulation of glucose metabolic process|
|negative regulation of protein secretion|
|positive regulation of small molecule metabolic process|
|regulation of cellular carbohydrate metabolic process|
|negative regulation of peptide secretion|
|positive regulation of lipid metabolic process|
|regulation of generation of precursor metabolites and energy|
|cellular response to insulin stimulus|
|positive regulation of protein kinase B signaling|
|regulation of cellular ketone metabolic process|
|regulation of insulin secretion|
|negative regulation of protein transport|
|glucose homeostasis|
|negative regulation of establishment of protein localization|
|carbohydrate homeostasis|
|positive regulation of transmembrane transport|
|negative regulation of secretion by cell|
|regulation of carbohydrate metabolic process|
|cellular response to acid chemical|
|regulation of peptide hormone secretion|
|regulation of protein kinase B signaling|
|response to insulin|
|negative regulation of secretion|
|cellular response to peptide hormone stimulus|
|regulation of hormone secretion|
|cellular response to peptide|
|response to acid chemical|
|positive regulation of cellular catabolic process|
|MAPK cascade|
|response to peptide hormone|
|signal transduction by protein phosphorylation|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|positive regulation of catabolic process|
|regulation of protein secretion|
|response to peptide|
|negative regulation of transport|
|regulation of peptide secretion|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cellular response to lipid|
|regulation of hormone levels|
|regulation of transmembrane transport|
|positive regulation of kinase activity|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|cytokine-mediated signaling pathway|
|intracellular membrane-bounded organelle|
|regulation of protein transport|
|enzyme linked receptor protein signaling pathway|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|regulation of cellular catabolic process|
|response to lipid|
|regulation of kinase activity|
|response to hormone|
|positive regulation of cell population proliferation|
|protein phosphorylation|
|regulation of transferase activity|
|positive regulation of transport|
|regulation of catabolic process|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|response to cytokine|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|phosphorylation|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of transport|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7430
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IRS1 Expression in NALM6 Cells: 5.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>