IRS1

Gene Information

Official Symbol: IRS1
Official Name: insulin receptor substrate 1
Aliases and Previous Symbols: N/A
Entrez ID: 3667
UniProt: P35568
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009].
UniProt Summary: May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). {ECO:0000250, ECO:0000269|PubMed:16878150}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 5/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	2/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7430
Expression level (log2 read counts): 5.77

Expression Distribution

PH
IRS

insulin receptor complex
positive regulation of fatty acid beta-oxidation
insulin-like growth factor receptor signaling pathway
transmembrane receptor protein tyrosine kinase adaptor activity
positive regulation of fatty acid oxidation
insulin-like growth factor receptor binding
positive regulation of glycogen biosynthetic process
positive regulation of glycogen metabolic process
regulation of fatty acid beta-oxidation
interleukin-7-mediated signaling pathway
phosphatidylinositol 3-kinase binding
positive regulation of insulin receptor signaling pathway
insulin receptor binding
positive regulation of cellular response to insulin stimulus
positive regulation of lipid catabolic process
cellular response to interleukin-7
regulation of glycogen biosynthetic process
regulation of glucan biosynthetic process
response to interleukin-7
regulation of fatty acid oxidation
positive regulation of phosphatidylinositol 3-kinase activity
phosphatidylinositol 3-kinase signaling
negative regulation of insulin receptor signaling pathway
positive regulation of fatty acid metabolic process
regulation of glycogen metabolic process
SH2 domain binding
negative regulation of cellular response to insulin stimulus
positive regulation of lipid kinase activity
regulation of polysaccharide biosynthetic process
positive regulation of glucose import
positive regulation of glucose metabolic process
negative regulation of insulin secretion
phosphotyrosine residue binding
regulation of polysaccharide metabolic process
positive regulation of glucose transmembrane transport
negative regulation of peptide hormone secretion
positive regulation of phospholipid metabolic process
regulation of phosphatidylinositol 3-kinase activity
SH3/SH2 adaptor activity
protein kinase C binding