ISG20

Entrez Summary: N/A
UniProt Summary: Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single- stranded DNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) in an exonuclease-dependent manner. May also play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis. {ECO:0000269|PubMed:11401564, ECO:0000269|PubMed:12594219, ECO:0000269|PubMed:16033969, ECO:0000269|PubMed:21036379}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

exoribonuclease II activity
DNA catabolic process, exonucleolytic
U2 snRNA binding
U3 snoRNA binding
single-stranded DNA 3-5 exodeoxyribonuclease activity
U1 snRNA binding
exonuclease activity
DNA catabolic process
3-5-exoribonuclease activity
RNA phosphodiester bond hydrolysis, exonucleolytic
Cajal body
negative regulation of viral genome replication
cellular response to type I interferon
type I interferon signaling pathway
response to type I interferon
negative regulation of viral life cycle
regulation of viral genome replication
negative regulation of viral process
PML body
regulation of viral life cycle
RNA phosphodiester bond hydrolysis
defense response to virus
regulation of viral process
rRNA processing
negative regulation of multi-organism process
regulation of symbiosis, encompassing mutualism through parasitism
rRNA metabolic process
RNA catabolic process
response to virus
nucleic acid phosphodiester bond hydrolysis
ribosome biogenesis
nucleobase-containing compound catabolic process
ncRNA processing
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
ribonucleoprotein complex biogenesis
ncRNA metabolic process
organic cyclic compound catabolic process
cytokine-mediated signaling pathway