ISL2

Entrez Summary: N/A
UniProt Summary: Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Homeobox
LIM

visceral motor neuron differentiation
peripheral nervous system neuron differentiation
peripheral nervous system neuron development
spinal cord motor neuron cell fate specification
retinal ganglion cell axon guidance
neuron fate specification
spinal cord motor neuron differentiation
ventral spinal cord development
cell differentiation in spinal cord
neuron fate commitment
peripheral nervous system development
cell fate specification
spinal cord development
central nervous system neuron differentiation
negative regulation of neuron differentiation
cell fate commitment
axon guidance
neuron projection guidance
negative regulation of neurogenesis
negative regulation of nervous system development
negative regulation of cell development
axonogenesis
axon development
sequence-specific DNA binding
cell morphogenesis involved in neuron differentiation
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
cell part morphogenesis
chemotaxis
taxis
cell morphogenesis involved in differentiation
regulation of neuron differentiation
neuron projection development
negative regulation of cell differentiation
cell morphogenesis
neuron development
regulation of neurogenesis
cellular component morphogenesis
regulation of nervous system development