ITCH
Gene Information
- Official Symbol: ITCH
- Official Name: itchy E3 ubiquitin protein ligase
- Aliases and Previous Symbols: N/A
- Entrez ID: 83737
- UniProt: Q96J02
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| WW |
| C2 |
| HECT |
GO Terms
| CXCR chemokine receptor binding |
| positive regulation of receptor catabolic process |
| protein K29-linked ubiquitination |
| arrestin family protein binding |
| regulation of receptor catabolic process |
| regulation of protein deubiquitination |
| ubiquitin-like protein ligase binding |
| negative regulation of defense response to virus |
| nucleotide-binding oligomerization domain containing signaling pathway |
| nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway |
| ribonucleoprotein complex binding |
| cytoplasmic pattern recognition receptor signaling pathway |
| negative regulation of JNK cascade |
| protein K63-linked ubiquitination |
| negative regulation of stress-activated protein kinase signaling cascade |
| negative regulation of stress-activated MAPK cascade |
| negative regulation of type I interferon production |
| protein K48-linked ubiquitination |
| protein autoubiquitination |
| regulation of hematopoietic stem cell differentiation |
| regulation of defense response to virus |
| negative regulation of NF-kappaB transcription factor activity |
| regulation of hematopoietic progenitor cell differentiation |
| negative regulation of response to biotic stimulus |
| viral entry into host cell |
| entry into host cell |
| entry into host |
| regulation of stem cell differentiation |
| negative regulation of immune effector process |
| Notch signaling pathway |
| regulation of type I interferon production |
| pattern recognition receptor signaling pathway |
| early endosome membrane |
| interaction with host |
| negative regulation of DNA-binding transcription factor activity |
| intracellular receptor signaling pathway |
| negative regulation of MAPK cascade |
| regulation of JNK cascade |
| defense response to virus |
| viral life cycle |
| negative regulation of defense response |
| negative regulation of multi-organism process |
| positive regulation of protein catabolic process |
| ubiquitin protein ligase activity |
| regulation of protein modification by small protein conjugation or removal |
| innate immune response-activating signal transduction |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| ubiquitin-protein transferase activity |
| early endosome |
| activation of innate immune response |
| negative regulation of cytokine production |
| response to virus |
| protein polyubiquitination |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| positive regulation of innate immune response |
| proteasomal protein catabolic process |
| positive regulation of response to biotic stimulus |
| negative regulation of response to external stimulus |
| positive regulation of cellular catabolic process |
| regulation of protein catabolic process |
| negative regulation of protein phosphorylation |
| regulation of cell growth |
| regulation of DNA-binding transcription factor activity |
| positive regulation of catabolic process |
| negative regulation of immune system process |
| negative regulation of phosphorylation |
| regulation of hemopoiesis |
| regulation of innate immune response |
| regulation of immune effector process |
| positive regulation of defense response |
| inflammatory response |
| negative regulation of intracellular signal transduction |
| positive regulation of multi-organism process |
| regulation of response to biotic stimulus |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| modification-dependent macromolecule catabolic process |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| immune response-activating signal transduction |
| proteolysis involved in cellular protein catabolic process |
| negative regulation of protein modification process |
| immune response-regulating signaling pathway |
| protein-containing complex |
| positive regulation of response to external stimulus |
| cellular protein catabolic process |
| activation of immune response |
| regulation of growth |
| protein catabolic process |
| intracellular membrane-bounded organelle |
| protein ubiquitination |
| regulation of cytokine production |
| viral process |
| regulation of proteolysis |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| regulation of defense response |
| innate immune response |
| protein modification by small protein conjugation |
| regulation of multi-organism process |
| symbiotic process |
| interspecies interaction between organisms |
| regulation of cellular catabolic process |
| positive regulation of immune response |
| negative regulation of apoptotic process |
| cellular macromolecule catabolic process |
| negative regulation of programmed cell death |
| apoptotic process |
| defense response to other organism |
| protein modification by small protein conjugation or removal |
| negative regulation of cell death |
| regulation of catabolic process |
| negative regulation of cellular protein metabolic process |
| macromolecule catabolic process |
| programmed cell death |
| organonitrogen compound catabolic process |
| immune effector process |
| cell death |
| regulation of response to external stimulus |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| regulation of immune response |
| positive regulation of immune system process |
| negative regulation of multicellular organismal process |
| negative regulation of signal transduction |
| proteolysis |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| regulation of protein phosphorylation |
| regulation of response to stress |
| regulation of apoptotic process |
| regulation of programmed cell death |
| regulation of phosphorylation |
| negative regulation of response to stimulus |
| regulation of immune system process |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| organic substance catabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| regulation of cell differentiation |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| immune response |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| LB-100 2μM R05 exp210 | 1.93 |
| Mdivi-1 15μM R05 exp217 | 2.22 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.447 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5809
- Expression level (log2 read counts): 6.08
Expression Distribution
ITCH Expression in NALM6 Cells: 6.08
