ITGA11

Entrez Summary: This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined. [provided by RefSeq, Jul 2008].
UniProt Summary: Integrin alpha-11/beta-1 is a receptor for collagen.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

integrin alpha11-beta1 complex
collagen receptor activity
collagen binding involved in cell-matrix adhesion
collagen-activated signaling pathway
cell adhesion mediated by integrin
integrin complex
substrate-dependent cell migration
collagen binding
integrin-mediated signaling pathway
osteoblast differentiation
cell-matrix adhesion
cell-substrate adhesion
ossification
muscle organ development
extracellular matrix organization
extracellular structure organization
focal adhesion
muscle structure development
cell adhesion
biological adhesion
cell migration
cell motility
localization of cell
locomotion
movement of cell or subcellular component
membrane