ITGAL [The Human Chemical-Genetic Interaction Map Project]

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======= ITGAL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ITGAL
  * **<color #00a2e8>Official Name</color>**: integrin subunit alpha L
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3683|3683]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P20701|P20701]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ITGAL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ITGAL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/153370|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin alpha-L/beta-2 is also a receptor for F11R (PubMed:11812992, PubMed:15528364). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992). Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity). Integrin alpha-L/beta-2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). {ECO:0000250|UniProtKB:P24063, ECO:0000269|PubMed:11812992, ECO:0000269|PubMed:15356110, ECO:0000269|PubMed:15528364, ECO:0000269|PubMed:23775590}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FG-GAP|
|Integrin alpha2|
|VWA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|integrin alphaL-beta2 complex|
|ICAM-3 receptor activity|
|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|
|integrin complex|
|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|
|receptor clustering|
|leukocyte cell-cell adhesion|
|cell adhesion molecule binding|
|T cell activation involved in immune response|
|localization within membrane|
|specific granule membrane|
|integrin-mediated signaling pathway|
|lymphocyte activation involved in immune response|
|cell-matrix adhesion|
|cell-substrate adhesion|
|T cell activation|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|protein-containing complex binding|
|phagocytosis|
|extracellular matrix organization|
|leukocyte migration|
|lymphocyte activation|
|extracellular structure organization|
|protein localization to membrane|
|neutrophil degranulation|
|protein heterodimerization activity|
|neutrophil activation involved in immune response|
|inflammatory response|
|neutrophil mediated immunity|
|neutrophil activation|
|cell-cell adhesion|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|myeloid leukocyte activation|
|cell surface|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|cell migration|
|secretion by cell|
|export from cell|
|cell activation|
|localization of cell|
|cell motility|
|immune effector process|
|secretion|
|regulation of immune response|
|locomotion|
|defense response|
|movement of cell or subcellular component|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of immune system process|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10606
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ITGAL Expression in NALM6 Cells: 1.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>