ITGAL

Entrez Summary: N/A
UniProt Summary: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin alpha-L/beta-2 is also a receptor for F11R (PubMed:11812992, PubMed:15528364). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992). Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity). Integrin alpha-L/beta-2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). {ECO:0000250|UniProtKB:P24063, ECO:0000269|PubMed:11812992, ECO:0000269|PubMed:15356110, ECO:0000269|PubMed:15528364, ECO:0000269|PubMed:23775590}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

integrin alphaL-beta2 complex
ICAM-3 receptor activity
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
integrin complex
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
receptor clustering
leukocyte cell-cell adhesion
cell adhesion molecule binding
T cell activation involved in immune response
localization within membrane
specific granule membrane
integrin-mediated signaling pathway
lymphocyte activation involved in immune response
cell-matrix adhesion
cell-substrate adhesion
T cell activation
cell-cell adhesion via plasma-membrane adhesion molecules
protein-containing complex binding
phagocytosis
extracellular matrix organization
leukocyte migration
lymphocyte activation
extracellular structure organization
protein localization to membrane
neutrophil degranulation
protein heterodimerization activity
neutrophil activation involved in immune response
inflammatory response
neutrophil mediated immunity
neutrophil activation
cell-cell adhesion
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
myeloid leukocyte activation
cell surface
leukocyte activation involved in immune response
cell activation involved in immune response
regulated exocytosis