ITGB1
Gene Information
- Official Symbol: ITGB1
- Official Name: integrin subunit beta 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 3688
- UniProt: P05556
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Integrin B tail |
| Integrin b cyt |
| Integrin beta |
GO Terms
| integrin alpha7-beta1 complex |
| integrin alpha3-beta1 complex |
| integrin alpha1-beta1 complex |
| integrin alpha11-beta1 complex |
| integrin alpha10-beta1 complex |
| integrin alpha8-beta1 complex |
| integrin alpha2-beta1 complex |
| formation of radial glial scaffolds |
| calcium-independent cell-matrix adhesion |
| regulation of collagen catabolic process |
| collagen binding involved in cell-matrix adhesion |
| C-X3-C chemokine binding |
| cell-cell adhesion mediated by integrin |
| integral component of synaptic membrane |
| invadopodium membrane |
| myelin sheath abaxonal region |
| germ cell migration |
| hindbrain radial glia guided cell migration |
| glial cell projection |
| cell migration in hindbrain |
| negative regulation of anoikis |
| stress fiber assembly |
| contractile actin filament bundle assembly |
| cellular response to low-density lipoprotein particle stimulus |
| leukocyte tethering or rolling |
| leukocyte adhesion to vascular endothelial cell |
| cell migration involved in sprouting angiogenesis |
| negative regulation of Rho protein signal transduction |
| basement membrane organization |
| cell adhesion mediated by integrin |
| laminin binding |
| regulation of anoikis |
| integrin complex |
| mesodermal cell differentiation |
| fibronectin binding |
| response to lipoprotein particle |
| cellular response to lipoprotein particle stimulus |
| blood vessel endothelial cell migration |
| positive regulation of signaling receptor activity |
| lamellipodium assembly |
| coreceptor activity |
| axon extension |
| heterotypic cell-cell adhesion |
| cellular extravasation |
| regulation of collagen metabolic process |
| lamellipodium organization |
| intercalated disc |
| sarcomere organization |
| visual learning |
| leukocyte cell-cell adhesion |
| negative regulation of Ras protein signal transduction |
| cellular defense response |
| visual behavior |
| cleavage furrow |
| positive regulation of protein localization to plasma membrane |
| sprouting angiogenesis |
| cell adhesion molecule binding |
| dendrite morphogenesis |
| negative regulation of small GTPase mediated signal transduction |
| neuron projection extension |
| positive regulation of protein localization to cell periphery |
| receptor internalization |
| actin filament bundle assembly |
| endothelial cell migration |
| actin filament bundle organization |
| myofibril assembly |
| mesoderm formation |
| mesoderm morphogenesis |
| filopodium |
| virus receptor activity |
| neuromuscular junction |
| associative learning |
| Schaffer collateral - CA1 synapse |
| epithelial cell migration |
| epithelium migration |
| cell fate specification |
| developmental cell growth |
| cardiac muscle cell differentiation |
| cell growth |
| ruffle |
| tissue migration |
| integrin-mediated signaling pathway |
| regulation of protein localization to plasma membrane |
| viral entry into host cell |
| ruffle membrane |
| sarcolemma |
| melanosome |
| entry into host |
| transforming growth factor beta receptor signaling pathway |
| dendrite development |
| entry into host cell |
| protease binding |
| cellular component assembly involved in morphogenesis |
| receptor metabolic process |
| B cell differentiation |
| formation of primary germ layer |
| regulation of protein localization to cell periphery |
| actomyosin structure organization |
| developmental growth involved in morphogenesis |
| cardiocyte differentiation |
| recycling endosome |
| G1/S transition of mitotic cell cycle |
| cell cycle G1/S phase transition |
| positive regulation of protein localization to membrane |
| mesoderm development |
| cell-matrix adhesion |
| integrin binding |
| striated muscle cell development |
| regulation of Rho protein signal transduction |
| learning |
| dendritic spine |
| muscle cell development |
| hindbrain development |
| B cell activation |
| cellular response to transforming growth factor beta stimulus |
| interaction with host |
| gastrulation |
| cardiac muscle tissue development |
| response to transforming growth factor beta |
| positive regulation of angiogenesis |
| positive regulation of protein kinase B signaling |
| homophilic cell adhesion via plasma membrane adhesion molecules |
| ameboidal-type cell migration |
| regulation of signaling receptor activity |
| lamellipodium |
| positive regulation of vasculature development |
| cell-substrate adhesion |
| regulation of protein localization to membrane |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| viral life cycle |
| striated muscle cell differentiation |
| receptor complex |
| regulation of protein kinase B signaling |
| membrane raft |
| receptor-mediated endocytosis |
| lymphocyte differentiation |
| actin filament organization |
| regulation of Ras protein signal transduction |
| muscle cell differentiation |
| cell fate commitment |
| cell-cell adhesion via plasma-membrane adhesion molecules |
| learning or memory |
| protein-containing complex binding |
| actin binding |
| mitotic cell cycle phase transition |
| cell cycle phase transition |
| striated muscle tissue development |
| regulation of angiogenesis |
| muscle tissue development |
| cognition |
| response to light stimulus |
| cadherin binding |
| angiogenesis |
| regulation of vasculature development |
| positive regulation of cellular protein localization |
| phagocytosis |
| leukocyte differentiation |
| extracellular matrix organization |
| regulation of small GTPase mediated signal transduction |
| glutamatergic synapse |
| cellular process involved in reproduction in multicellular organism |
| axonogenesis |
| in utero embryonic development |
| leukocyte migration |
| lymphocyte activation |
| extracellular structure organization |
| developmental growth |
| growth |
| external side of plasma membrane |
| blood vessel morphogenesis |
| axon development |
| positive regulation of GTPase activity |
| focal adhesion |
| cell morphogenesis involved in neuron differentiation |
| response to radiation |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| plasma membrane bounded cell projection assembly |
| supramolecular fiber organization |
| cell projection assembly |
| muscle structure development |
| neuron projection morphogenesis |
| regulation of GTPase activity |
| plasma membrane bounded cell projection morphogenesis |
| blood vessel development |
| protein heterodimerization activity |
| cell projection morphogenesis |
| actin cytoskeleton organization |
| cellular response to growth factor stimulus |
| positive regulation of cell migration |
| cell-cell adhesion |
| negative regulation of intracellular signal transduction |
| vasculature development |
| cell part morphogenesis |
| cardiovascular system development |
| positive regulation of cell motility |
| heart development |
| response to growth factor |
| positive regulation of cellular component movement |
| regulation of cellular protein localization |
| positive regulation of locomotion |
| endocytosis |
| cell morphogenesis involved in differentiation |
| hemopoiesis |
| tissue morphogenesis |
| embryonic morphogenesis |
| actin filament-based process |
| behavior |
| protein-containing complex |
| mitotic cell cycle process |
| hematopoietic or lymphoid organ development |
| cell surface |
| chordate embryonic development |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| immune system development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| neuron projection development |
| cytokine-mediated signaling pathway |
| import into cell |
| mitotic cell cycle |
| gamete generation |
| perinuclear region of cytoplasm |
| positive regulation of cell death |
| viral process |
| negative regulation of cell differentiation |
| enzyme linked receptor protein signaling pathway |
| cell morphogenesis |
| brain development |
| organelle assembly |
| positive regulation of hydrolase activity |
| head development |
| symbiotic process |
| neuron development |
| interspecies interaction between organisms |
| cellular component morphogenesis |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| tube development |
| regulation of cell migration |
| circulatory system development |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| negative regulation of programmed cell death |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| regulation of cellular localization |
| leukocyte activation |
| cell adhesion |
| biological adhesion |
| negative regulation of developmental process |
| cell migration |
| embryo development |
| central nervous system development |
| regulation of locomotion |
| regulation of catabolic process |
| negative regulation of cell death |
| multi-organism reproductive process |
| regulation of cellular component movement |
| cell cycle process |
| response to organonitrogen compound |
| cellular response to cytokine stimulus |
| neuron differentiation |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| regulation of anatomical structure morphogenesis |
| cell activation |
| cell motility |
| localization of cell |
| response to nitrogen compound |
| response to cytokine |
| cytoskeleton organization |
| plasma membrane bounded cell projection organization |
| regulation of immune response |
| cell projection organization |
| response to abiotic stimulus |
| regulation of cell cycle |
| cellular response to endogenous stimulus |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| locomotion |
| defense response |
| cell cycle |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| nervous system process |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| response to endogenous stimulus |
| generation of neurons |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| regulation of programmed cell death |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| cell development |
| regulation of immune system process |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of molecular function |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| vesicle-mediated transport |
| system process |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Nocodazole 0.02μM R00 exp23 | -2.53 |
| Bisphenol A 100μM R06 exp269 | -2.46 |
| Etoposide 1μM R00 exp19 | -2.08 |
| ABT-702 5μM R06 exp261 | 1.79 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 18/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 3/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 1/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 1/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 3/75 |
| lymphocyte | 0/16 |
| ovary | 1/26 |
| pancreas | 2/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 3/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14914
- Expression level (log2 read counts): 7.8
Expression Distribution
ITGB1 Expression in NALM6 Cells: 7.8
