ITGB3BP

Entrez Summary: This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Colchicine 0.009μM R05 exp215	-2.04
Betulinic acid 10 to 15μM on day4 R05 exp222	1.71
Dimethyl-Sulfoxide 1pc R03 exp120	1.74

CENP-A containing nucleosome assembly
CENP-A containing chromatin organization
chromatin remodeling at centromere
centromere complex assembly
DNA replication-independent nucleosome assembly
DNA replication-independent nucleosome organization
histone exchange
ATP-dependent chromatin remodeling
condensed chromosome kinetochore
nucleosome assembly
chromatin assembly
chromatin assembly or disassembly
nucleosome organization
chromatin remodeling
DNA packaging
protein C-terminus binding
protein-DNA complex assembly
protein-DNA complex subunit organization
DNA conformation change
cell division
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
chromatin organization
cellular protein-containing complex assembly
apoptotic process
cell adhesion
biological adhesion
programmed cell death
chromosome organization
cell death
cell cycle
regulation of apoptotic process
protein-containing complex assembly
regulation of programmed cell death
regulation of cell death
protein-containing complex subunit organization
membrane