ITGB5 [The Human Chemical-Genetic Interaction Map Project]

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======= ITGB5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ITGB5
  * **<color #00a2e8>Official Name</color>**: integrin subunit beta 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3693|3693]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P18084|P18084]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ITGB5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ITGB5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147561|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Integrin b cyt|
|Integrin beta|
|Integrin B tail|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|integrin alphav-beta5 complex|
|epithelial cell-cell adhesion|
|contractile actin filament bundle assembly|
|stress fiber assembly|
|cell adhesion mediated by integrin|
|integrin complex|
|endodermal cell differentiation|
|endoderm formation|
|phagocytic vesicle|
|actin filament bundle assembly|
|actin filament bundle organization|
|endoderm development|
|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|
|virus receptor activity|
|antigen processing and presentation of exogenous peptide antigen via MHC class I|
|integrin-mediated signaling pathway|
|viral entry into host cell|
|antigen processing and presentation of peptide antigen via MHC class I|
|entry into host cell|
|transforming growth factor beta receptor signaling pathway|
|entry into host|
|formation of primary germ layer|
|actomyosin structure organization|
|cell-matrix adhesion|
|integrin binding|
|cellular response to transforming growth factor beta stimulus|
|interaction with host|
|gastrulation|
|response to transforming growth factor beta|
|antigen processing and presentation of exogenous peptide antigen|
|antigen processing and presentation of exogenous antigen|
|cell-substrate adhesion|
|antigen processing and presentation of peptide antigen|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|viral life cycle|
|signaling receptor activity|
|receptor complex|
|antigen processing and presentation|
|actin filament organization|
|muscle contraction|
|muscle system process|
|extracellular matrix organization|
|extracellular structure organization|
|focal adhesion|
|supramolecular fiber organization|
|actin cytoskeleton organization|
|cellular response to growth factor stimulus|
|cell-cell adhesion|
|response to growth factor|
|embryonic morphogenesis|
|actin filament-based process|
|cell surface|
|viral process|
|enzyme linked receptor protein signaling pathway|
|symbiotic process|
|interspecies interaction between organisms|
|anatomical structure formation involved in morphogenesis|
|cell adhesion|
|biological adhesion|
|cell migration|
|embryo development|
|localization of cell|
|cell motility|
|cytoskeleton organization|
|cellular response to endogenous stimulus|
|locomotion|
|response to endogenous stimulus|
|movement of cell or subcellular component|
|tissue development|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 30/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|0/28|
|bone|2/26|
|breast|3/33|
|central nervous system|6/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|2/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|2/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|2/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4896
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.44 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ITGB5 Expression in NALM6 Cells: -0.44'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>