ITGB5

Entrez Summary: N/A
UniProt Summary: Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 30/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	3/28
blood	0/28
bone	2/26
breast	3/33
central nervous system	6/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	2/20
lung	2/75
lymphocyte	0/16
ovary	1/26
pancreas	2/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	2/29
uterus	1/5

Expression Distribution

integrin alphav-beta5 complex
epithelial cell-cell adhesion
contractile actin filament bundle assembly
stress fiber assembly
cell adhesion mediated by integrin
integrin complex
endodermal cell differentiation
endoderm formation
phagocytic vesicle
actin filament bundle assembly
actin filament bundle organization
endoderm development
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
virus receptor activity
antigen processing and presentation of exogenous peptide antigen via MHC class I
integrin-mediated signaling pathway
viral entry into host cell
antigen processing and presentation of peptide antigen via MHC class I
entry into host cell
transforming growth factor beta receptor signaling pathway
entry into host
formation of primary germ layer
actomyosin structure organization
cell-matrix adhesion
integrin binding
cellular response to transforming growth factor beta stimulus
interaction with host
gastrulation
response to transforming growth factor beta
antigen processing and presentation of exogenous peptide antigen
antigen processing and presentation of exogenous antigen
cell-substrate adhesion
antigen processing and presentation of peptide antigen
transmembrane receptor protein serine/threonine kinase signaling pathway
viral life cycle
signaling receptor activity
receptor complex
antigen processing and presentation
actin filament organization
muscle contraction