ITPKA
Gene Information
- Official Symbol: ITPKA
- Official Name: inositol-trisphosphate 3-kinase A
- Aliases and Previous Symbols: N/A
- Entrez ID: 3706
- UniProt: P23677
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| IPK |
GO Terms
| inositol-1,4,5-trisphosphate 3-kinase activity |
| dendritic spine maintenance |
| inositol metabolic process |
| positive regulation of dendritic spine morphogenesis |
| calmodulin-dependent protein kinase activity |
| inositol phosphate biosynthetic process |
| dendritic spine organization |
| positive regulation of dendrite morphogenesis |
| neuron projection organization |
| regulation of dendritic spine morphogenesis |
| positive regulation of dendritic spine development |
| cellular component maintenance |
| Rac GTPase binding |
| inositol phosphate metabolic process |
| polyol biosynthetic process |
| regulation of dendritic spine development |
| positive regulation of dendrite development |
| postsynapse organization |
| regulation of dendrite morphogenesis |
| regulation of postsynapse organization |
| polyol metabolic process |
| alcohol biosynthetic process |
| dendritic spine |
| regulation of dendrite development |
| positive regulation of cell morphogenesis involved in differentiation |
| cellular carbohydrate metabolic process |
| organic hydroxy compound biosynthetic process |
| regulation of synaptic plasticity |
| calmodulin binding |
| regulation of synapse organization |
| regulation of synapse structure or activity |
| synapse organization |
| positive regulation of neuron projection development |
| regulation of cell morphogenesis involved in differentiation |
| alcohol metabolic process |
| positive regulation of neuron differentiation |
| positive regulation of cell projection organization |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| organic hydroxy compound metabolic process |
| positive regulation of neurogenesis |
| carbohydrate metabolic process |
| regulation of cell morphogenesis |
| actin cytoskeleton organization |
| regulation of neuron projection development |
| positive regulation of nervous system development |
| organophosphate biosynthetic process |
| positive regulation of cell development |
| actin filament-based process |
| small molecule biosynthetic process |
| regulation of neuron differentiation |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cell projection organization |
| regulation of neurogenesis |
| organophosphate metabolic process |
| regulation of nervous system development |
| regulation of cell development |
| positive regulation of cell differentiation |
| protein phosphorylation |
| regulation of anatomical structure morphogenesis |
| cytoskeleton organization |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| positive regulation of cellular component organization |
| phosphorylation |
| positive regulation of developmental process |
| ATP binding |
| generation of neurons |
| neurogenesis |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| regulation of cell differentiation |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Bortezomib 0.05μM R00 exp7 | -1.92 |
| Cyclosporin-A 3μM R07 exp348 | -1.79 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4043
- Expression level (log2 read counts): 0.25
Expression Distribution
ITPKA Expression in NALM6 Cells: 0.25
