ITPR3

Entrez Summary: This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010].
UniProt Summary: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
inositol hexakisphosphate binding
inositol 1,3,4,5 tetrakisphosphate binding
sensory perception of sweet taste
sensory perception of umami taste
platelet dense tubular network membrane
calcium-release channel activity
inositol 1,4,5 trisphosphate binding
inositol phosphate-mediated signaling
nuclear outer membrane
myelin sheath
sarcoplasmic reticulum
sensory perception of bitter taste
long-term synaptic potentiation
brush border
release of sequestered calcium ion into cytosol
negative regulation of sequestering of calcium ion
sensory perception of taste
calcium ion transmembrane import into cytosol
regulation of cardiac conduction
apical part of cell
calcium ion transport into cytosol
phosphatidylinositol binding
cytosolic calcium ion transport
secretory granule membrane
protein heterooligomerization
memory
regulation of sequestering of calcium ion
platelet activation
cytoplasmic vesicle membrane
response to calcium ion
positive regulation of synaptic transmission
regulation of insulin secretion
regulation of synaptic plasticity
calcium ion transmembrane transport
receptor complex
regulation of peptide hormone secretion
regulation of heart contraction
calcium ion transport
learning or memory