IVL [The Human Chemical-Genetic Interaction Map Project]

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======= IVL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IVL
  * **<color #00a2e8>Official Name</color>**: involucrin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3713|3713]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P07476|P07476]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IVL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IVL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147360|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase.  This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Involucrin N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|
|isopeptide cross-linking|
|peptidyl-glutamine modification|
|response to UV-B|
|peptide cross-linking|
|cornified envelope|
|cornification|
|response to UV|
|keratinization|
|keratinocyte differentiation|
|nuclear body|
|response to light stimulus|
|peptidyl-lysine modification|
|epidermal cell differentiation|
|skin development|
|epidermis development|
|response to radiation|
|centrosome|
|epithelial cell differentiation|
|peptidyl-amino acid modification|
|programmed cell death|
|cell death|
|epithelium development|
|response to abiotic stimulus|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-2.8|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.39|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-2.12|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|-2.05|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-1.76|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.7|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|1.82|
|[[:results:exp136|MS094 2μM R03 exp136]]|1.87|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2978
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IVL Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>