IVL

Entrez Summary: Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008].
UniProt Summary: Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
RO-3307 4.7μM R02 exp80	-2.8
Ethanol 0.01 R05 exp234	-2.39
MLN-4924 0.2μM R00 exp21	-2.12
GSK-J4 1-1.25μM to day4 R07 exp363	-2.05
THZ531 0.11 to 0.125μM on day4 R07 exp410	-1.76
R-DABN 8μM R03 exp111	1.7
Rapamycin 1μM R00 exp29	1.82
MS094 2μM R03 exp136	1.87
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	1.91

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine
isopeptide cross-linking
peptidyl-glutamine modification
response to UV-B
peptide cross-linking
cornified envelope
cornification
response to UV
keratinization
keratinocyte differentiation
nuclear body
response to light stimulus
peptidyl-lysine modification
epidermal cell differentiation
skin development
epidermis development
response to radiation
centrosome
epithelial cell differentiation
peptidyl-amino acid modification
programmed cell death
cell death
epithelium development
response to abiotic stimulus
tissue development