JAG1 [The Human Chemical-Genetic Interaction Map Project]

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======= JAG1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: JAG1
  * **<color #00a2e8>Official Name</color>**: jagged canonical Notch ligand 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=182|182]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P78504|P78504]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=JAG1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20JAG1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601920|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein.  Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch.  Mutations that alter the jagged 1 protein cause Alagille syndrome.  Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro). {ECO:0000250, ECO:0000269|PubMed:18660822, ECO:0000269|PubMed:9462510}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EGF|
|DSL|
|MNNL|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endocardial cushion cell development|
|endocardial cushion cell differentiation|
|ciliary body morphogenesis|
|cardiac neural crest cell development involved in outflow tract morphogenesis|
|pulmonary artery morphogenesis|
|cardiac neural crest cell differentiation involved in heart development|
|cardiac neural crest cell development involved in heart development|
|positive regulation of cardiac epithelial to mesenchymal transition|
|glomerular visceral epithelial cell development|
|negative regulation of endothelial cell differentiation|
|glomerular epithelial cell development|
|Notch signaling involved in heart development|
|regulation of cardiac epithelial to mesenchymal transition|
|loop of Henle development|
|distal tubule development|
|renal filtration cell differentiation|
|glomerular visceral epithelial cell differentiation|
|pulmonary valve morphogenesis|
|glomerular epithelial cell differentiation|
|glomerular epithelium development|
|cardiac right ventricle morphogenesis|
|response to muramyl dipeptide|
|pulmonary valve development|
|negative regulation of stem cell differentiation|
|neuronal stem cell population maintenance|
|cell surface receptor signaling pathway involved in heart development|
|inner ear auditory receptor cell differentiation|
|Notch binding|
|aorta morphogenesis|
|aortic valve morphogenesis|
|epithelial cell differentiation involved in kidney development|
|aortic valve development|
|blood vessel remodeling|
|regulation of endothelial cell differentiation|
|hair cell differentiation|
|myoblast differentiation|
|semi-lunar valve development|
|negative regulation of cell-matrix adhesion|
|cell fate determination|
|regulation of heart morphogenesis|
|negative regulation of epithelial cell differentiation|
|cell differentiation involved in kidney development|
|T cell mediated immunity|
|negative regulation of Notch signaling pathway|
|endocardial cushion development|
|neuroepithelial cell differentiation|
|negative regulation of fat cell differentiation|
|positive regulation of epithelial to mesenchymal transition|
|morphogenesis of an epithelial sheet|
|aorta development|
|glomerulus development|
|inner ear receptor cell differentiation|
|positive regulation of Notch signaling pathway|
|heart valve morphogenesis|
|mechanoreceptor differentiation|
|positive regulation of osteoblast differentiation|
|artery morphogenesis|
|heart valve development|
|negative regulation of cell-substrate adhesion|
|adherens junction|
|cardiac cell development|
|cardiac ventricle morphogenesis|
|outflow tract morphogenesis|
|cardiac septum morphogenesis|
|nephron tubule development|
|neural crest cell development|
|renal tubule development|
|positive regulation of animal organ morphogenesis|
|endothelial cell differentiation|
|regulation of epithelial to mesenchymal transition|
|stem cell development|
|mesenchymal cell development|
|positive regulation of ossification|
|artery development|
|neural crest cell differentiation|
|positive regulation of myeloid cell differentiation|
|columnar/cuboidal epithelial cell differentiation|
|endothelium development|
|nephron epithelium development|
|tissue remodeling|
|regulation of Notch signaling pathway|
|phospholipid binding|
|cardiac septum development|
|camera-type eye morphogenesis|
|regulation of osteoblast differentiation|
|regulation of cell-matrix adhesion|
|cardiocyte differentiation|
|regulation of stem cell differentiation|
|regulation of fat cell differentiation|
|nephron development|
|Notch signaling pathway|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|kidney epithelium development|
|stem cell population maintenance|
|maintenance of cell number|
|regulation of epithelial cell differentiation|
|eye morphogenesis|
|mesenchymal cell differentiation|
|stem cell differentiation|
|growth factor activity|
|cardiac chamber development|
|negative regulation of cell-cell adhesion|
|positive regulation of hemopoiesis|
|regulation of ossification|
|structural molecule activity|
|epithelial cell development|
|inner ear development|
|regulation of cell-substrate adhesion|
|ear development|
|mesenchyme development|
|negative regulation of neuron differentiation|
|regulation of myeloid cell differentiation|
|cell fate commitment|
|heart morphogenesis|
|sensory organ morphogenesis|
|regulation of animal organ morphogenesis|
|negative regulation of cell migration|
|lymphocyte mediated immunity|
|kidney development|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|keratinocyte differentiation|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|renal system development|
|negative regulation of neurogenesis|
|negative regulation of cellular component movement|
|negative regulation of nervous system development|
|camera-type eye development|
|epidermal cell differentiation|
|angiogenesis|
|urogenital system development|
|apical plasma membrane|
|negative regulation of locomotion|
|negative regulation of cell development|
|eye development|
|visual system development|
|sensory system development|
|skin development|
|regulation of cell-cell adhesion|
|blood vessel morphogenesis|
|epidermis development|
|morphogenesis of an epithelium|
|regulation of hemopoiesis|
|response to peptide|
|muscle structure development|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|heart development|
|sensory organ development|
|hemopoiesis|
|tissue morphogenesis|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|immune system development|
|tube morphogenesis|
|regulation of neuron differentiation|
|regulation of cell adhesion|
|epithelial cell differentiation|
|negative regulation of cell differentiation|
|calcium ion binding|
|leukocyte mediated immunity|
|regulation of neurogenesis|
|tube development|
|regulation of cell migration|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|regulation of locomotion|
|regulation of cellular component movement|
|response to organonitrogen compound|
|neuron differentiation|
|response to drug|
|regulation of anatomical structure morphogenesis|
|response to nitrogen compound|
|immune effector process|
|epithelium development|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|integral component of plasma membrane|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9732
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='JAG1 Expression in NALM6 Cells: 1.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>