JAG1
Gene Information
- Official Symbol: JAG1
- Official Name: jagged canonical Notch ligand 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 182
- UniProt: P78504
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008].
- UniProt Summary: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro). {ECO:0000250, ECO:0000269|PubMed:18660822, ECO:0000269|PubMed:9462510}.
Pfam Domains GO Terms
Pfam Domains
| EGF |
| DSL |
| MNNL |
GO Terms
| endocardial cushion cell development |
| endocardial cushion cell differentiation |
| ciliary body morphogenesis |
| cardiac neural crest cell development involved in outflow tract morphogenesis |
| pulmonary artery morphogenesis |
| cardiac neural crest cell differentiation involved in heart development |
| cardiac neural crest cell development involved in heart development |
| positive regulation of cardiac epithelial to mesenchymal transition |
| glomerular visceral epithelial cell development |
| negative regulation of endothelial cell differentiation |
| glomerular epithelial cell development |
| Notch signaling involved in heart development |
| regulation of cardiac epithelial to mesenchymal transition |
| loop of Henle development |
| distal tubule development |
| renal filtration cell differentiation |
| glomerular visceral epithelial cell differentiation |
| pulmonary valve morphogenesis |
| glomerular epithelial cell differentiation |
| glomerular epithelium development |
| cardiac right ventricle morphogenesis |
| response to muramyl dipeptide |
| pulmonary valve development |
| negative regulation of stem cell differentiation |
| neuronal stem cell population maintenance |
| cell surface receptor signaling pathway involved in heart development |
| inner ear auditory receptor cell differentiation |
| Notch binding |
| aorta morphogenesis |
| aortic valve morphogenesis |
| epithelial cell differentiation involved in kidney development |
| aortic valve development |
| blood vessel remodeling |
| regulation of endothelial cell differentiation |
| hair cell differentiation |
| myoblast differentiation |
| semi-lunar valve development |
| negative regulation of cell-matrix adhesion |
| cell fate determination |
| regulation of heart morphogenesis |
| negative regulation of epithelial cell differentiation |
| cell differentiation involved in kidney development |
| T cell mediated immunity |
| negative regulation of Notch signaling pathway |
| endocardial cushion development |
| neuroepithelial cell differentiation |
| negative regulation of fat cell differentiation |
| positive regulation of epithelial to mesenchymal transition |
| morphogenesis of an epithelial sheet |
| aorta development |
| glomerulus development |
| inner ear receptor cell differentiation |
| positive regulation of Notch signaling pathway |
| heart valve morphogenesis |
| mechanoreceptor differentiation |
| positive regulation of osteoblast differentiation |
| artery morphogenesis |
| heart valve development |
| negative regulation of cell-substrate adhesion |
| adherens junction |
| cardiac cell development |
| cardiac ventricle morphogenesis |
| outflow tract morphogenesis |
| cardiac septum morphogenesis |
| nephron tubule development |
| neural crest cell development |
| renal tubule development |
| positive regulation of animal organ morphogenesis |
| endothelial cell differentiation |
| regulation of epithelial to mesenchymal transition |
| stem cell development |
| mesenchymal cell development |
| positive regulation of ossification |
| artery development |
| neural crest cell differentiation |
| positive regulation of myeloid cell differentiation |
| columnar/cuboidal epithelial cell differentiation |
| endothelium development |
| nephron epithelium development |
| tissue remodeling |
| regulation of Notch signaling pathway |
| phospholipid binding |
| cardiac septum development |
| camera-type eye morphogenesis |
| regulation of osteoblast differentiation |
| regulation of cell-matrix adhesion |
| cardiocyte differentiation |
| regulation of stem cell differentiation |
| regulation of fat cell differentiation |
| nephron development |
| Notch signaling pathway |
| cardiac chamber morphogenesis |
| cardiac ventricle development |
| kidney epithelium development |
| stem cell population maintenance |
| maintenance of cell number |
| regulation of epithelial cell differentiation |
| eye morphogenesis |
| mesenchymal cell differentiation |
| stem cell differentiation |
| growth factor activity |
| cardiac chamber development |
| negative regulation of cell-cell adhesion |
| positive regulation of hemopoiesis |
| regulation of ossification |
| structural molecule activity |
| epithelial cell development |
| inner ear development |
| regulation of cell-substrate adhesion |
| ear development |
| mesenchyme development |
| negative regulation of neuron differentiation |
| regulation of myeloid cell differentiation |
| cell fate commitment |
| heart morphogenesis |
| sensory organ morphogenesis |
| regulation of animal organ morphogenesis |
| negative regulation of cell migration |
| lymphocyte mediated immunity |
| kidney development |
| negative regulation of cell adhesion |
| negative regulation of cell motility |
| keratinocyte differentiation |
| adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| renal system development |
| negative regulation of neurogenesis |
| negative regulation of cellular component movement |
| negative regulation of nervous system development |
| camera-type eye development |
| epidermal cell differentiation |
| angiogenesis |
| urogenital system development |
| apical plasma membrane |
| negative regulation of locomotion |
| negative regulation of cell development |
| eye development |
| visual system development |
| sensory system development |
| skin development |
| regulation of cell-cell adhesion |
| blood vessel morphogenesis |
| epidermis development |
| morphogenesis of an epithelium |
| regulation of hemopoiesis |
| response to peptide |
| muscle structure development |
| blood vessel development |
| vasculature development |
| cardiovascular system development |
| heart development |
| sensory organ development |
| hemopoiesis |
| tissue morphogenesis |
| hematopoietic or lymphoid organ development |
| adaptive immune response |
| immune system development |
| tube morphogenesis |
| regulation of neuron differentiation |
| regulation of cell adhesion |
| epithelial cell differentiation |
| negative regulation of cell differentiation |
| calcium ion binding |
| leukocyte mediated immunity |
| regulation of neurogenesis |
| tube development |
| regulation of cell migration |
| circulatory system development |
| anatomical structure formation involved in morphogenesis |
| regulation of cell motility |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| animal organ morphogenesis |
| positive regulation of cell differentiation |
| regulation of locomotion |
| regulation of cellular component movement |
| response to organonitrogen compound |
| neuron differentiation |
| response to drug |
| regulation of anatomical structure morphogenesis |
| response to nitrogen compound |
| immune effector process |
| epithelium development |
| positive regulation of immune system process |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| integral component of plasma membrane |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| response to oxygen-containing compound |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| regulation of immune system process |
| positive regulation of signal transduction |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| membrane |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Dinaciclib 0.007μM R07 exp355 | 1.81 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 9732
- Expression level (log2 read counts): 1.05
Expression Distribution
JAG1 Expression in NALM6 Cells: 1.05
