JMJD1C [The Human Chemical-Genetic Interaction Map Project]

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======= JMJD1C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: JMJD1C
  * **<color #00a2e8>Official Name</color>**: jumonji domain containing 1C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=221037|221037]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15652|Q15652]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=JMJD1C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20JMJD1C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604503|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the DNA-damage response pathway by demethylating the mediator of DNA damage checkpoint 1 (MDC1) protein, and is required for the survival of acute myeloid leukemia. Mutations in this gene are associated with Rett syndrome and intellectual disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|JmjC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone demethylase activity (H3-K9 specific)|
|histone H3-K9 demethylation|
|dioxygenase activity|
|histone lysine demethylation|
|histone demethylation|
|thyroid hormone receptor binding|
|protein demethylation|
|protein dealkylation|
|demethylation|
|chromatin DNA binding|
|transcription regulatory region sequence-specific DNA binding|
|chromatin|
|blood coagulation|
|coagulation|
|hemostasis|
|histone modification|
|covalent chromatin modification|
|wound healing|
|regulation of body fluid levels|
|response to wounding|
|chromatin organization|
|oxidation-reduction process|
|chromosome organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.74|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.77|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.81|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|2.63|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.471|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12995
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='JMJD1C Expression in NALM6 Cells: 7.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>