JMJD1C

Entrez Summary: The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the DNA-damage response pathway by demethylating the mediator of DNA damage checkpoint 1 (MDC1) protein, and is required for the survival of acute myeloid leukemia. Mutations in this gene are associated with Rett syndrome and intellectual disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
MK-1775 0.32μM R02 exp75	1.74
Pterostilbene 16μM R02 exp78	1.77
KU-0063794 3.8μM R02 exp71	1.81
All-trans-Retinoic-Acid 40μM R07 exp334	2.63

histone demethylase activity (H3-K9 specific)
histone H3-K9 demethylation
dioxygenase activity
histone lysine demethylation
histone demethylation
thyroid hormone receptor binding
protein demethylation
protein dealkylation
demethylation
chromatin DNA binding
transcription regulatory region sequence-specific DNA binding
chromatin
blood coagulation
coagulation
hemostasis
histone modification
covalent chromatin modification
wound healing
regulation of body fluid levels
response to wounding
chromatin organization
oxidation-reduction process
chromosome organization