JUNB [The Human Chemical-Genetic Interaction Map Project]

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======= JUNB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: JUNB
  * **<color #00a2e8>Official Name</color>**: JunB proto-oncogene, AP-1 transcription factor subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3726|3726]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P17275|P17275]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=JUNB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20JUNB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/165161|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|bZIP 1|
|Jun|
|bZIP 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|osteoblast proliferation|
|transcription factor AP-1 complex|
|embryonic process involved in female pregnancy|
|trophectodermal cell differentiation|
|labyrinthine layer blood vessel development|
|decidualization|
|placenta blood vessel development|
|maternal placenta development|
|blastocyst formation|
|osteoclast differentiation|
|labyrinthine layer development|
|maternal process involved in female pregnancy|
|vasculogenesis|
|cellular response to calcium ion|
|embryonic placenta development|
|blastocyst development|
|response to cAMP|
|myeloid leukocyte differentiation|
|chromatin|
|osteoblast differentiation|
|response to organophosphorus|
|response to calcium ion|
|response to purine-containing compound|
|placenta development|
|female pregnancy|
|cellular response to metal ion|
|transcription factor complex|
|multi-multicellular organism process|
|response to mechanical stimulus|
|myeloid cell differentiation|
|cellular response to inorganic substance|
|nuclear chromatin|
|transcription corepressor activity|
|ossification|
|transcription coactivator activity|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|leukocyte differentiation|
|transcription factor binding|
|response to metal ion|
|in utero embryonic development|
|blood vessel morphogenesis|
|reproductive structure development|
|reproductive system development|
|embryonic organ development|
|response to radiation|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|blood vessel development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|vasculature development|
|cardiovascular system development|
|response to inorganic substance|
|cell population proliferation|
|hemopoiesis|
|cellular response to hormone stimulus|
|hematopoietic or lymphoid organ development|
|chordate embryonic development|
|immune system development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|developmental process involved in reproduction|
|cytokine-mediated signaling pathway|
|response to bacterium|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|tube development|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|response to organic cyclic compound|
|positive regulation of cell differentiation|
|embryo development|
|multi-organism reproductive process|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|response to drug|
|response to nitrogen compound|
|response to cytokine|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17882
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='JUNB Expression in NALM6 Cells: 4.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>