JUNB
Gene Information
- Official Symbol: JUNB
- Official Name: JunB proto-oncogene, AP-1 transcription factor subunit
- Aliases and Previous Symbols: N/A
- Entrez ID: 3726
- UniProt: P17275
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'.
Pfam Domains GO Terms
Pfam Domains
| bZIP 1 |
| Jun |
| bZIP 2 |
GO Terms
| osteoblast proliferation |
| transcription factor AP-1 complex |
| embryonic process involved in female pregnancy |
| trophectodermal cell differentiation |
| labyrinthine layer blood vessel development |
| decidualization |
| placenta blood vessel development |
| maternal placenta development |
| blastocyst formation |
| osteoclast differentiation |
| labyrinthine layer development |
| maternal process involved in female pregnancy |
| vasculogenesis |
| cellular response to calcium ion |
| embryonic placenta development |
| blastocyst development |
| response to cAMP |
| myeloid leukocyte differentiation |
| chromatin |
| osteoblast differentiation |
| response to organophosphorus |
| response to calcium ion |
| response to purine-containing compound |
| placenta development |
| female pregnancy |
| cellular response to metal ion |
| transcription factor complex |
| multi-multicellular organism process |
| response to mechanical stimulus |
| myeloid cell differentiation |
| cellular response to inorganic substance |
| nuclear chromatin |
| transcription corepressor activity |
| ossification |
| transcription coactivator activity |
| response to lipopolysaccharide |
| response to molecule of bacterial origin |
| leukocyte differentiation |
| transcription factor binding |
| response to metal ion |
| in utero embryonic development |
| blood vessel morphogenesis |
| reproductive structure development |
| reproductive system development |
| embryonic organ development |
| response to radiation |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| blood vessel development |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| vasculature development |
| cardiovascular system development |
| response to inorganic substance |
| cell population proliferation |
| hemopoiesis |
| cellular response to hormone stimulus |
| hematopoietic or lymphoid organ development |
| chordate embryonic development |
| immune system development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| developmental process involved in reproduction |
| cytokine-mediated signaling pathway |
| response to bacterium |
| multicellular organismal reproductive process |
| multicellular organism reproduction |
| tube development |
| response to lipid |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| anatomical structure formation involved in morphogenesis |
| response to hormone |
| response to organic cyclic compound |
| positive regulation of cell differentiation |
| embryo development |
| multi-organism reproductive process |
| response to organonitrogen compound |
| cellular response to cytokine stimulus |
| response to drug |
| response to nitrogen compound |
| response to cytokine |
| response to abiotic stimulus |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| negative regulation of nucleobase-containing compound metabolic process |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| tissue development |
| regulation of cell differentiation |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RRM1 | 0.406 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 5/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 1/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 1/16 |
| ovary | 0/26 |
| pancreas | 1/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 1/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 1/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17882
- Expression level (log2 read counts): 4.11
Expression Distribution
JUNB Expression in NALM6 Cells: 4.11
