KAL1 [The Human Chemical-Genetic Interaction Map Project]

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======= KAL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ANOS1
  * **<color #00a2e8>Official Name</color>**: anosmin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3730|3730]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P23352|P23352]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KAL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KAL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300836|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Mutations in this gene cause the X-linked Kallmann syndrome. The encoded protein is similar in sequence to proteins known to function in neural cell adhesion and axonal migration. In addition, this cell surface protein is N-glycosylated and may have anti-protease activity. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Has a dual branch-promoting and guidance activity, which may play an important role in the patterning of mitral and tufted cell collaterals to the olfactory cortex (By similarity). Chemoattractant for fetal olfactory epithelial cells. {ECO:0000250, ECO:0000269|PubMed:19696444}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|fn3|
|WAP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|fibroblast growth factor receptor signaling pathway|
|serine-type endopeptidase inhibitor activity|
|cellular response to fibroblast growth factor stimulus|
|response to fibroblast growth factor|
|extracellular matrix structural constituent|
|heparin binding|
|extracellular matrix|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|axon guidance|
|neuron projection guidance|
|negative regulation of proteolysis|
|axonogenesis|
|axon development|
|regulation of endopeptidase activity|
|cell morphogenesis involved in neuron differentiation|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|response to growth factor|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|neuron projection development|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|regulation of proteolysis|
|negative regulation of catalytic activity|
|neuron development|
|cellular component morphogenesis|
|cell adhesion|
|biological adhesion|
|neuron differentiation|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|cell projection organization|
|cellular response to endogenous stimulus|
|regulation of hydrolase activity|
|locomotion|
|response to endogenous stimulus|
|generation of neurons|
|movement of cell or subcellular component|
|extracellular space|
|neurogenesis|
|cell development|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18868
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KAL1 Expression in NALM6 Cells: 2.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>