KAL1

Entrez Summary: Mutations in this gene cause the X-linked Kallmann syndrome. The encoded protein is similar in sequence to proteins known to function in neural cell adhesion and axonal migration. In addition, this cell surface protein is N-glycosylated and may have anti-protease activity. [provided by RefSeq, Jul 2008].
UniProt Summary: Has a dual branch-promoting and guidance activity, which may play an important role in the patterning of mitral and tufted cell collaterals to the olfactory cortex (By similarity). Chemoattractant for fetal olfactory epithelial cells. {ECO:0000250, ECO:0000269|PubMed:19696444}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

fn3
WAP

fibroblast growth factor receptor signaling pathway
serine-type endopeptidase inhibitor activity
cellular response to fibroblast growth factor stimulus
response to fibroblast growth factor
extracellular matrix structural constituent
heparin binding
extracellular matrix
negative regulation of endopeptidase activity
negative regulation of peptidase activity
axon guidance
neuron projection guidance
negative regulation of proteolysis
axonogenesis
axon development
regulation of endopeptidase activity
cell morphogenesis involved in neuron differentiation
regulation of peptidase activity
negative regulation of hydrolase activity
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
cellular response to growth factor stimulus
transmembrane receptor protein tyrosine kinase signaling pathway
cell part morphogenesis
response to growth factor
chemotaxis
taxis
cell morphogenesis involved in differentiation
neuron projection development
enzyme linked receptor protein signaling pathway
cell morphogenesis
regulation of proteolysis
negative regulation of catalytic activity
neuron development
cellular component morphogenesis
cell adhesion
biological adhesion
neuron differentiation
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process