KAT2B [The Human Chemical-Genetic Interaction Map Project]

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======= KAT2B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KAT2B
  * **<color #00a2e8>Official Name</color>**: lysine acetyltransferase 2B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8850|8850]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92831|Q92831]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KAT2B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KAT2B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602303|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Acetyltransf 1|
|Bromodomain|
|PCAF N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone H3-K9 acetylation|
|N-terminal peptidyl-lysine acetylation|
|diamine N-acetyltransferase activity|
|positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter|
|PCAF complex|
|peptide-lysine-N-acetyltransferase activity|
|lysine N-acetyltransferase activity, acting on acetyl phosphate as donor|
|regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter|
|negative regulation of centriole replication|
|regulation of protein ADP-ribosylation|
|cyclin-dependent protein serine/threonine kinase inhibitor activity|
|negative regulation of centrosome duplication|
|regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter|
|A band|
|positive regulation of gluconeogenesis|
|actomyosin|
|negative regulation of centrosome cycle|
|N-terminal protein amino acid acetylation|
|Ada2/Gcn5/Ada3 transcription activator complex|
|positive regulation of transcription of Notch receptor target|
|acetyltransferase activity|
|histone H3-K9 modification|
|I band|
|regulation of centriole replication|
|N-terminal protein amino acid modification|
|negative regulation of cyclin-dependent protein serine/threonine kinase activity|
|negative regulation of cyclin-dependent protein kinase activity|
|positive regulation of glucose metabolic process|
|negative regulation of organelle assembly|
|regulation of centrosome duplication|
|regulation of gluconeogenesis|
|histone H3 acetylation|
|histone acetyltransferase activity|
|positive regulation of Notch signaling pathway|
|regulation of megakaryocyte differentiation|
|positive regulation of cellular carbohydrate metabolic process|
|regulation of centrosome cycle|
|positive regulation of gene expression, epigenetic|
|positive regulation of carbohydrate metabolic process|
|transcription coregulator activity|
|kinetochore|
|regulation of carbohydrate biosynthetic process|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|regulation of cyclin-dependent protein kinase activity|
|regulation of Notch signaling pathway|
|histone deacetylase binding|
|histone acetylation|
|regulation of glucose metabolic process|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|Notch signaling pathway|
|negative regulation of protein serine/threonine kinase activity|
|positive regulation of small molecule metabolic process|
|regulation of cellular carbohydrate metabolic process|
|negative regulation of cytoskeleton organization|
|protein acetylation|
|cell cycle arrest|
|chromatin remodeling|
|cellular response to insulin stimulus|
|transcription initiation from RNA polymerase II promoter|
|appendage development|
|limb development|
|protein acylation|
|regulation of microtubule cytoskeleton organization|
|regulation of carbohydrate metabolic process|
|DNA-templated transcription, initiation|
|regulation of organelle assembly|
|regulation of microtubule-based process|
|negative regulation of protein kinase activity|
|regulation of myeloid cell differentiation|
|protein maturation|
|response to insulin|
|regulation of gene expression, epigenetic|
|negative regulation of kinase activity|
|cellular response to peptide hormone stimulus|
|rhythmic process|
|negative regulation of transferase activity|
|protein deubiquitination|
|transcription coactivator activity|
|protein modification by small protein removal|
|peptidyl-lysine modification|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|negative regulation of cell cycle process|
|cellular response to peptide|
|transcription factor binding|
|histone modification|
|negative regulation of organelle organization|
|covalent chromatin modification|
|response to peptide hormone|
|chromatin binding|
|negative regulation of protein phosphorylation|
|regulation of small molecule metabolic process|
|negative regulation of phosphorylation|
|regulation of hemopoiesis|
|protein kinase binding|
|response to peptide|
|transcription by RNA polymerase II|
|centrosome|
|regulation of protein serine/threonine kinase activity|
|heart development|
|regulation of cytoskeleton organization|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of cell cycle|
|negative regulation of protein modification process|
|protein-containing complex|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|cellular response to nitrogen compound|
|negative regulation of cell population proliferation|
|chromatin organization|
|viral process|
|negative regulation of cellular component organization|
|regulation of cell cycle process|
|symbiotic process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|circulatory system development|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|response to hormone|
|regulation of cellular component biogenesis|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|cell cycle process|
|response to organonitrogen compound|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|chromosome organization|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|proteolysis|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|cell cycle|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14314
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KAT2B Expression in NALM6 Cells: 4.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>