KCND1

Entrez Summary: This gene encodes a multipass membrane protein that comprises the pore subunit of the voltage-gated A-type potassium channel, which functions in the repolarization of membrane action potentials. Activity of voltage-gated potassium channels is important in a number of physiological processes, among them the regulation of neurotransmitter release, heart rate, insulin secretion, and smooth muscle contraction. [provided by RefSeq, Aug 2013].
UniProt Summary: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

Screen	Score
Cannabidiol 13μM R08 exp465	-1.83
Dimethyloxaloylglycine 11μM R07 exp314	1.7
Methotrexate 0.01μM R08 exp501	1.71
INK128 0.2μM R02 exp70	1.94

voltage-gated potassium channel activity
voltage-gated potassium channel complex
cardiac conduction
multicellular organismal signaling
potassium ion transmembrane transport
potassium ion transport
regulation of heart contraction
regulation of blood circulation
protein homooligomerization
neuronal cell body
monovalent inorganic cation transport
dendrite
cellular component
regulation of ion transmembrane transport
protein complex oligomerization
inorganic cation transmembrane transport
regulation of transmembrane transport
regulation of system process
cation transmembrane transport
metal ion transport
inorganic ion transmembrane transport
regulation of ion transport
cation transport
ion transmembrane transport
transmembrane transport
ion transport
protein-containing complex assembly
protein-containing complex subunit organization
regulation of transport