KCNE3

Gene Information

Official Symbol: KCNE3
Official Name: potassium voltage-gated channel subfamily E regulatory subunit 3
Aliases and Previous Symbols: N/A
Entrez ID: 10008
UniProt: Q9Y6H6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the kidney. A missense mutation in this gene is associated with hypokalemic periodic paralysis. [provided by RefSeq, Jul 2008].
UniProt Summary: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed:12954870). Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion that produces a current with nearly instantaneous activation with a linear current-voltage relationship. {ECO:0000250|UniProtKB:Q9JJV7, ECO:0000269|PubMed:10646604, ECO:0000269|PubMed:12954870}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14085
Expression level (log2 read counts): 2.05

Expression Distribution

negative regulation of membrane repolarization during cardiac muscle cell action potential
negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential
negative regulation of cardiac muscle cell contraction
negative regulation of ventricular cardiac muscle cell action potential
negative regulation of potassium ion export across plasma membrane
regulation of membrane repolarization during ventricular cardiac muscle cell action potential
regulation of membrane repolarization during cardiac muscle cell action potential
negative regulation of cardiac muscle contraction
regulation of potassium ion export across plasma membrane
negative regulation of striated muscle contraction
negative regulation of action potential
regulation of membrane repolarization during action potential
negative regulation of delayed rectifier potassium channel activity
positive regulation of voltage-gated calcium channel activity
negative regulation of voltage-gated potassium channel activity
membrane repolarization during ventricular cardiac muscle cell action potential
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
ventricular cardiac muscle cell membrane repolarization
regulation of ventricular cardiac muscle cell action potential
potassium ion export across plasma membrane
regulation of delayed rectifier potassium channel activity
cardiac muscle cell membrane repolarization
membrane repolarization during cardiac muscle cell action potential
membrane repolarization during action potential
negative regulation of potassium ion transmembrane transporter activity
ventricular cardiac muscle cell action potential
membrane repolarization
negative regulation of muscle contraction
regulation of ventricular cardiac muscle cell membrane repolarization
negative regulation of heart contraction
negative regulation of potassium ion transmembrane transport
regulation of cardiac muscle cell membrane repolarization
neuronal cell body membrane
regulation of cardiac muscle cell action potential
negative regulation of potassium ion transport
negative regulation of blood circulation
delayed rectifier potassium channel activity
regulation of membrane repolarization
regulation of voltage-gated calcium channel activity
regulation of heart rate by cardiac conduction