KCNE4 [The Human Chemical-Genetic Interaction Map Project]

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======= KCNE4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KCNE4
  * **<color #00a2e8>Official Name</color>**: potassium voltage-gated channel subfamily E regulatory subunit 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23704|23704]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WWG9|Q8WWG9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KCNE4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KCNE4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607775|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ISK Channel|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of delayed rectifier potassium channel activity|
|negative regulation of voltage-gated potassium channel activity|
|ventricular cardiac muscle cell membrane repolarization|
|voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|
|membrane repolarization during ventricular cardiac muscle cell action potential|
|potassium ion export across plasma membrane|
|regulation of delayed rectifier potassium channel activity|
|membrane repolarization during action potential|
|membrane repolarization during cardiac muscle cell action potential|
|cardiac muscle cell membrane repolarization|
|negative regulation of potassium ion transmembrane transporter activity|
|membrane repolarization|
|ventricular cardiac muscle cell action potential|
|regulation of ventricular cardiac muscle cell membrane repolarization|
|negative regulation of potassium ion transmembrane transport|
|regulation of cardiac muscle cell membrane repolarization|
|negative regulation of potassium ion transport|
|delayed rectifier potassium channel activity|
|regulation of membrane repolarization|
|regulation of heart rate by cardiac conduction|
|cardiac muscle cell action potential involved in contraction|
|export across plasma membrane|
|potassium channel regulator activity|
|cardiac muscle cell contraction|
|negative regulation of cation channel activity|
|cardiac muscle cell action potential|
|regulation of potassium ion transmembrane transporter activity|
|negative regulation of ion transmembrane transporter activity|
|cardiac muscle contraction|
|negative regulation of transporter activity|
|regulation of potassium ion transmembrane transport|
|negative regulation of cation transmembrane transport|
|voltage-gated potassium channel complex|
|heart contraction|
|actin-mediated cell contraction|
|cardiac conduction|
|action potential|
|regulation of potassium ion transport|
|negative regulation of ion transmembrane transport|
|regulation of heart rate|
|heart process|
|striated muscle contraction|
|actin filament-based movement|
|negative regulation of transmembrane transport|
|ion channel binding|
|multicellular organismal signaling|
|negative regulation of ion transport|
|potassium ion transmembrane transport|
|potassium ion transport|
|regulation of cation channel activity|
|regulation of heart contraction|
|muscle contraction|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|regulation of transporter activity|
|regulation of blood circulation|
|muscle system process|
|apical plasma membrane|
|regulation of cation transmembrane transport|
|regulation of metal ion transport|
|blood circulation|
|circulatory system process|
|monovalent inorganic cation transport|
|regulation of membrane potential|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|actin filament-based process|
|regulation of system process|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|regulation of ion transport|
|cation transport|
|ion transmembrane transport|
|export from cell|
|negative regulation of molecular function|
|transmembrane transport|
|ion transport|
|movement of cell or subcellular component|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15239
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KCNE4 Expression in NALM6 Cells: 3.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>