KCNE4

Gene Information

Official Symbol: KCNE4
Official Name: potassium voltage-gated channel subfamily E regulatory subunit 4
Aliases and Previous Symbols: N/A
Entrez ID: 23704
UniProt: Q8WWG9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15239
Expression level (log2 read counts): 3.34

Expression Distribution

negative regulation of delayed rectifier potassium channel activity
negative regulation of voltage-gated potassium channel activity
ventricular cardiac muscle cell membrane repolarization
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
membrane repolarization during ventricular cardiac muscle cell action potential
potassium ion export across plasma membrane
regulation of delayed rectifier potassium channel activity
membrane repolarization during action potential
membrane repolarization during cardiac muscle cell action potential
cardiac muscle cell membrane repolarization
negative regulation of potassium ion transmembrane transporter activity
membrane repolarization
ventricular cardiac muscle cell action potential
regulation of ventricular cardiac muscle cell membrane repolarization
negative regulation of potassium ion transmembrane transport
regulation of cardiac muscle cell membrane repolarization
negative regulation of potassium ion transport
delayed rectifier potassium channel activity
regulation of membrane repolarization
regulation of heart rate by cardiac conduction
cardiac muscle cell action potential involved in contraction
export across plasma membrane
potassium channel regulator activity
cardiac muscle cell contraction
negative regulation of cation channel activity
cardiac muscle cell action potential
regulation of potassium ion transmembrane transporter activity
negative regulation of ion transmembrane transporter activity
cardiac muscle contraction
negative regulation of transporter activity
regulation of potassium ion transmembrane transport
negative regulation of cation transmembrane transport
voltage-gated potassium channel complex
heart contraction
actin-mediated cell contraction
cardiac conduction
action potential
regulation of potassium ion transport
negative regulation of ion transmembrane transport
regulation of heart rate