KCNIP3

Entrez Summary: N/A
UniProt Summary: Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity). {ECO:0000250|UniProtKB:Q9QXT8}. May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of amyloid-beta formation. {ECO:0000269|PubMed:11259376, ECO:0000269|PubMed:11988022, ECO:0000269|PubMed:9771752}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

potassium channel activity
potassium channel regulator activity
protein-DNA complex
voltage-gated ion channel activity
axon terminus
regulation of potassium ion transmembrane transport
voltage-gated potassium channel complex
cardiac conduction
regulation of potassium ion transport
ion channel binding
multicellular organismal signaling
potassium ion transmembrane transport
potassium ion transport
protein localization to plasma membrane
protein localization to cell periphery
transcription corepressor activity
regulation of heart contraction
DNA-binding transcription repressor activity, RNA polymerase II-specific
regulation of blood circulation
regulation of cation transmembrane transport
regulation of metal ion transport
monovalent inorganic cation transport
dendrite
regulation of ion transmembrane transport
protein localization to membrane
RNA polymerase II proximal promoter sequence-specific DNA binding
inorganic cation transmembrane transport
regulation of transmembrane transport
regulation of system process
cation transmembrane transport
metal ion transport
inorganic ion transmembrane transport
regulation of ion transport
calcium ion binding
cation transport
negative regulation of transcription by RNA polymerase II
apoptotic process
ion transmembrane transport
Golgi apparatus
intracellular protein transport