KCNS3

Gene Information

Official Symbol: KCNS3
Official Name: potassium voltage-gated channel modifier subfamily S member 3
Aliases and Previous Symbols: N/A
Entrez ID: 3790
UniProt: Q9BQ31
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013].
UniProt Summary: Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:10484328). Heterotetrameric channel activity formed with KCNB1 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity). {ECO:0000250|UniProtKB:O88759, ECO:0000269|PubMed:10484328}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12527
Expression level (log2 read counts): 4.68

Expression Distribution

Screen	Score
MLN-4924 0.2μM R00 exp21	-1.88
Glyphosate 1000μM R06 exp283	1.76

Ion trans 2
Ion trans
K tetra

delayed rectifier potassium channel activity
potassium channel regulator activity
voltage-gated potassium channel activity
voltage-gated potassium channel complex
potassium ion transmembrane transport
potassium ion transport
regulation of insulin secretion
regulation of peptide hormone secretion
regulation of hormone secretion
protein homooligomerization
monovalent inorganic cation transport
regulation of protein secretion
regulation of ion transmembrane transport
regulation of peptide secretion
protein complex oligomerization
regulation of hormone levels
inorganic cation transmembrane transport
regulation of transmembrane transport
cation transmembrane transport
metal ion transport
inorganic ion transmembrane transport
regulation of ion transport
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
regulation of secretion by cell
regulation of secretion
cation transport
ion transmembrane transport
Golgi apparatus
regulation of protein localization
transmembrane transport
ion transport
protein-containing complex assembly
protein-containing complex subunit organization
regulation of transport