KCNT2

Entrez Summary: N/A
UniProt Summary: Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. Activated by high intracellular sodium and chloride levels. Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane (By similarity). Inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. {ECO:0000250, ECO:0000269|PubMed:14684870, ECO:0000269|PubMed:16687497}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
SNS-032 25μM R07 exp401	-1.85
Dimethyl-Sulfoxide 1pc R03 exp120	1.82

BK channel a
Ion trans 2

chloride-activated potassium channel activity
intracellular sodium activated potassium channel activity
outward rectifier potassium channel activity
potassium ion export across plasma membrane
export across plasma membrane
potassium ion transmembrane transport
potassium ion transport
monovalent inorganic cation transport
regulation of membrane potential
inorganic cation transmembrane transport
cation transmembrane transport
metal ion transport
inorganic ion transmembrane transport
cation transport
ion transmembrane transport
export from cell
transmembrane transport
ion transport
ATP binding