KCTD11

Gene Information

Official Symbol: KCTD11
Official Name: potassium channel tetramerization domain containing 11
Aliases and Previous Symbols: N/A
Entrez ID: 147040
UniProt: Q693B1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock-down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade. {ECO:0000269|PubMed:15249678, ECO:0000269|PubMed:20081843, ECO:0000269|PubMed:21237243}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13194
Expression level (log2 read counts): 1.28

Expression Distribution

negative regulation of neuroblast proliferation
negative regulation of stem cell proliferation
negative regulation of neural precursor cell proliferation
negative regulation of smoothened signaling pathway
regulation of neuroblast proliferation
transferase activity
regulation of stem cell proliferation
regulation of smoothened signaling pathway
regulation of neural precursor cell proliferation
negative regulation of neurogenesis
negative regulation of nervous system development
negative regulation of cell development
protein homooligomerization
positive regulation of neuron differentiation
positive regulation of neurogenesis
protein complex oligomerization
positive regulation of nervous system development
positive regulation of cell development
regulation of neuron differentiation
regulation of growth
negative regulation of cell population proliferation
protein ubiquitination
negative regulation of cell differentiation
protein modification by small protein conjugation
regulation of neurogenesis
regulation of nervous system development
regulation of cell development
negative regulation of developmental process
positive regulation of cell differentiation
protein modification by small protein conjugation or removal
identical protein binding
negative regulation of multicellular organismal process
negative regulation of signal transduction
cell cycle
negative regulation of cell communication
negative regulation of signaling
positive regulation of developmental process
generation of neurons
protein-containing complex assembly
regulation of cell population proliferation