KDELR1 [The Human Chemical-Genetic Interaction Map Project]

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======= KDELR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KDELR1
  * **<color #00a2e8>Official Name</color>**: KDEL endoplasmic reticulum protein retention receptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10945|10945]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P24390|P24390]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KDELR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KDELR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/131235|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for the retention of luminal endoplasmic reticulum resident proteins via vesicular recycling. This receptor recognizes the C-terminal K-D-E-L motif. COPI-coated transport intermediates, either in the form of round vesicles or as tubular processes, mediate retrograde traffic of the KDEL receptor-ligand complexes. Also required for normal vesicular traffic through the Golgi. {ECO:0000269|PubMed:11703931}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ER lumen recept|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|KDEL sequence binding|
|COPI-coated vesicle membrane|
|protein retention in ER lumen|
|T cell cytokine production|
|maintenance of protein localization in endoplasmic reticulum|
|T cell apoptotic process|
|lymphocyte apoptotic process|
|cytokine production involved in immune response|
|leukocyte apoptotic process|
|maintenance of protein localization in organelle|
|T cell mediated immunity|
|cis-Golgi network|
|endoplasmic reticulum-Golgi intermediate compartment membrane|
|maintenance of protein location in cell|
|endoplasmic reticulum-Golgi intermediate compartment|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|transport vesicle|
|maintenance of location in cell|
|maintenance of protein location|
|T cell differentiation|
|protein localization to endoplasmic reticulum|
|cytokine production|
|maintenance of location|
|production of molecular mediator of immune response|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|T cell activation|
|lymphocyte differentiation|
|lymphocyte mediated immunity|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|leukocyte differentiation|
|Golgi vesicle transport|
|lymphocyte activation|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|Golgi membrane|
|immune system development|
|protein localization to organelle|
|leukocyte mediated immunity|
|apoptotic process|
|leukocyte activation|
|endoplasmic reticulum membrane|
|Golgi apparatus|
|endoplasmic reticulum|
|programmed cell death|
|cell activation|
|immune effector process|
|cell death|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-1.94|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-1.9|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-1.86|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|1.81|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|1.94|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|2.05|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.2|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.21|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|1/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13469
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KDELR1 Expression in NALM6 Cells: 6.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>