KDELR1

Entrez Summary: N/A
UniProt Summary: Required for the retention of luminal endoplasmic reticulum resident proteins via vesicular recycling. This receptor recognizes the C-terminal K-D-E-L motif. COPI-coated transport intermediates, either in the form of round vesicles or as tubular processes, mediate retrograde traffic of the KDEL receptor-ligand complexes. Also required for normal vesicular traffic through the Golgi. {ECO:0000269|PubMed:11703931}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Momordin-Ic 10μM R08 exp506	-1.94
All-trans-Retinoic-Acid 40μM R07 exp334	-1.9
Cycloheximide 0.2μM R00 exp15	-1.86
Glyphosate 1000μM R06 exp283	1.81
Deguelin 0.15μM R05 exp209	1.94
Clomiphene 4.4μM R02 exp68	2.05
Vemurafenib 6.6μM R08 exp434	2.2
Vemurafenib 6.6μM R02 exp89	2.21

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	1/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

KDEL sequence binding
COPI-coated vesicle membrane
protein retention in ER lumen
T cell cytokine production
maintenance of protein localization in endoplasmic reticulum
T cell apoptotic process
lymphocyte apoptotic process
cytokine production involved in immune response
leukocyte apoptotic process
maintenance of protein localization in organelle
T cell mediated immunity
cis-Golgi network
endoplasmic reticulum-Golgi intermediate compartment membrane
maintenance of protein location in cell
endoplasmic reticulum-Golgi intermediate compartment
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
transport vesicle
maintenance of location in cell
maintenance of protein location
T cell differentiation
protein localization to endoplasmic reticulum
cytokine production
maintenance of location
production of molecular mediator of immune response
endoplasmic reticulum to Golgi vesicle-mediated transport
T cell activation
lymphocyte differentiation
lymphocyte mediated immunity
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
leukocyte differentiation
Golgi vesicle transport
lymphocyte activation
hemopoiesis
hematopoietic or lymphoid organ development
adaptive immune response
Golgi membrane
immune system development
protein localization to organelle
leukocyte mediated immunity
apoptotic process