KDM4C
Gene Information
- Official Symbol: KDM4C
- Official Name: lysine demethylase 4C
- Aliases and Previous Symbols: N/A
- Entrez ID: 23081
- UniProt: Q9H3R0
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| JmjC |
| JmjN |
GO Terms
| negative regulation of histone H3-K9 trimethylation |
| histone demethylase activity (H3-K36 specific) |
| histone H3-K36 demethylation |
| regulation of histone H3-K9 trimethylation |
| negative regulation of histone H3-K9 methylation |
| pericentric heterochromatin |
| histone demethylase activity (H3-K9 specific) |
| histone H3-K9 demethylation |
| histone demethylase activity |
| negative regulation of histone methylation |
| regulation of histone H3-K9 methylation |
| histone lysine demethylation |
| histone demethylation |
| protein dealkylation |
| protein demethylation |
| blastocyst formation |
| negative regulation of histone modification |
| histone methyltransferase complex |
| androgen receptor binding |
| negative regulation of chromatin organization |
| demethylation |
| regulation of histone methylation |
| blastocyst development |
| regulation of stem cell differentiation |
| negative regulation of chromosome organization |
| stem cell population maintenance |
| maintenance of cell number |
| regulation of histone modification |
| chromatin remodeling |
| regulation of chromatin organization |
| nuclear chromatin |
| enzyme binding |
| regulation of chromosome organization |
| histone modification |
| positive regulation of neuron differentiation |
| negative regulation of organelle organization |
| covalent chromatin modification |
| in utero embryonic development |
| chromatin binding |
| positive regulation of neurogenesis |
| positive regulation of nervous system development |
| positive regulation of cell development |
| negative regulation of protein modification process |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| regulation of neuron differentiation |
| chromatin organization |
| negative regulation of cellular component organization |
| regulation of neurogenesis |
| zinc ion binding |
| anatomical structure formation involved in morphogenesis |
| positive regulation of cell population proliferation |
| regulation of nervous system development |
| regulation of cell development |
| oxidation-reduction process |
| positive regulation of cell differentiation |
| embryo development |
| negative regulation of cellular protein metabolic process |
| chromosome organization |
| negative regulation of protein metabolic process |
| regulation of organelle organization |
| positive regulation of developmental process |
| generation of neurons |
| regulation of cell population proliferation |
| neurogenesis |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
| regulation of protein modification process |
| positive regulation of gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Ethanol 0.003 R08 exp437 | -1.88 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4384
- Expression level (log2 read counts): 5.7
Expression Distribution
KDM4C Expression in NALM6 Cells: 5.7
