KEL

Entrez Summary: This gene encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen. The Kell glycoprotein links via a single disulfide bond to the XK membrane protein that carries the Kx antigen. The encoded protein contains sequence and structural similarity to members of the neprilysin (M13) family of zinc endopeptidases. [provided by RefSeq, Jul 2008].
UniProt Summary: Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3. {ECO:0000269|PubMed:10438732}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Peptidase M13
Peptidase M13 N

cellular magnesium ion homeostasis
regulation of axon diameter
magnesium ion homeostasis
regulation of cell projection size
skeletal muscle fiber development
negative regulation of potassium ion transmembrane transport
myotube cell development
vasoconstriction
negative regulation of potassium ion transport
negative regulation of blood vessel diameter
myotube differentiation
muscle fiber development
regulation of potassium ion transmembrane transport
negative regulation of cation transmembrane transport
negative regulation of ion transmembrane transport
regulation of potassium ion transport
metalloendopeptidase activity
myelination
axon ensheathment
ensheathment of neurons
negative regulation of transmembrane transport
skeletal muscle tissue development
skeletal muscle organ development
striated muscle cell development
regulation of tube diameter
regulation of blood vessel diameter
regulation of tube size
negative regulation of ion transport
muscle cell development
vascular process in circulatory system
regulation of cell size
regulation of axonogenesis
striated muscle cell differentiation
muscle cell differentiation
striated muscle tissue development
muscle organ development
muscle tissue development
regulation of cell morphogenesis involved in differentiation
regulation of cation transmembrane transport
regulation of cellular component size