KERA

Entrez Summary: The protein encoded by this gene is a keratan sulfate proteoglycan that is involved in corneal transparency. Defects in this gene are a cause of autosomal recessive cornea plana 2 (CNA2).[provided by RefSeq, May 2010].
UniProt Summary: May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix. {ECO:0000305|PubMed:10802664, ECO:0000305|PubMed:11726611}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

LRR 4
LRRNT

cornea development in camera-type eye
keratan sulfate catabolic process
keratan sulfate biosynthetic process
keratan sulfate metabolic process
sulfur compound catabolic process
glycosaminoglycan catabolic process
aminoglycan catabolic process
lysosomal lumen
Golgi lumen
glycosaminoglycan biosynthetic process
mucopolysaccharide metabolic process
aminoglycan biosynthetic process
glycosaminoglycan metabolic process
aminoglycan metabolic process
sulfur compound biosynthetic process
carbohydrate derivative catabolic process
visual perception
sensory perception of light stimulus
extracellular matrix
camera-type eye development
eye development
visual system development
sulfur compound metabolic process
sensory system development
sensory organ development
carbohydrate derivative biosynthetic process
molecular function
sensory perception
oxoacid metabolic process
organic acid metabolic process
carbohydrate derivative metabolic process
macromolecule catabolic process
organonitrogen compound catabolic process
nervous system process
organonitrogen compound biosynthetic process
small molecule metabolic process
macromolecule biosynthetic process
organic substance catabolic process
cellular catabolic process
extracellular region