KIAA0101

Entrez Summary: N/A
UniProt Summary: PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number. {ECO:0000269|PubMed:21673012, ECO:0000269|PubMed:23000965}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

translesion synthesis
DNA synthesis involved in DNA repair
postreplication repair
centrosome cycle
microtubule organizing center organization
DNA biosynthetic process
response to UV
DNA replication
response to light stimulus
chromatin binding
response to radiation
microtubule cytoskeleton organization
centrosome
DNA repair
microtubule-based process
perinuclear region of cytoplasm
DNA metabolic process
cellular response to DNA damage stimulus
cell cycle process
nucleobase-containing compound biosynthetic process
cytoskeleton organization
response to abiotic stimulus
heterocycle biosynthetic process
aromatic compound biosynthetic process
regulation of cell cycle
organic cyclic compound biosynthetic process
cell cycle
cellular nitrogen compound biosynthetic process
cellular response to stress
cellular macromolecule biosynthetic process
macromolecule biosynthetic process