KIAA0319

Entrez Summary: This gene encodes a transmembrane protein that contains a large extracellular domain with multiple polycystic kidney disease (PKD) domains. The encoded protein may play a role in the development of the cerebral cortex by regulating neuronal migration and cell adhesion. Single nucleotide polymorphisms in this gene are associated with dyslexia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Radicicol 0.16μM R05 exp242	-2.07
Deguelin 0.15μM R05 exp209	1.85

response to auditory stimulus
negative regulation of dendrite development
clathrin-coated vesicle membrane
neuron migration
regulation of dendrite development
early endosome membrane
negative regulation of neuron projection development
negative regulation of cell projection organization
response to mechanical stimulus
negative regulation of neuron differentiation
cytoplasmic vesicle
early endosome
negative regulation of neurogenesis
negative regulation of nervous system development
negative regulation of cell development
regulation of neuron projection development
regulation of neuron differentiation
intracellular membrane-bounded organelle
regulation of plasma membrane bounded cell projection organization
negative regulation of cellular component organization
regulation of cell projection organization
negative regulation of cell differentiation
regulation of neurogenesis
membrane organization
regulation of nervous system development
regulation of cell development
negative regulation of developmental process
cell migration
localization of cell
cell motility
response to abiotic stimulus
negative regulation of multicellular organismal process
locomotion
generation of neurons
movement of cell or subcellular component
neurogenesis
regulation of cell differentiation